Chimeric exosomes bring new ideas for tumor immunotherapy

Science and Technology Daily, Beijing, October 21 (Reporter Lu Chengkuan) On the 21st, the reporter learned from the Institute of Process Engineering of the Chinese Academy of Sciences that the researchers of the Institute created a chimeric exosome that achieved dual targeting of lymph nodes and tumor tissues.

Exosomes are a kind of vesicle-type natural biological particles secreted by cells.

"Most of the existing tumor immunotherapy focuses on improving the function and number of immune cells in the body, but it is usually difficult to overcome the immunosuppressive microenvironment of solid tumors, making it difficult for the immune cells infiltrated in the tumor to effectively exert their anti-tumor functions

To this end, the researchers combined with more than ten years of experience in granular formulations, vaccine delivery and tumor immunity, and proposed a new strategy for lymph node-tumor dual-targeted exosomes for dual-effect synergistic tumor immunotherapy

Wei Wei, a researcher at the Institute of Process Engineering of the Chinese Academy of Sciences, said that this result is a pre-clinical study, and the actual clinical efficacy still needs to be further verified