China has found the world's first adult HIV antibody negative AIDS combined KS case

Recently, reporters from Beijing Concord Hospital learned that the hospital respiratory medicine, infection medicine, pathology jointly reported the world's first adult HIV antibody negative AIDS combined lung kaposi sarcoma case, published in the latest issue of the Journal of Clinical Respiratory medicine
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the patient, a middle-age male, was referred to several hospitals in China for two months for sore throat, healing, fever and breathing difficulties, and his symptoms did not ease, and he later went to Concord Hospital. Hospitalization examination found double lung multi-block-like shadow, CD4 positive T lymphocytes only 6 /mm3 (average 760 normal people), HIV screening test suspicious positive, but confirmed that the test was negative. After a biopsy of the lung puncture, pathologists found under the mirror that the lung lesion was Kaposi sarcoma (KS), which is good in people with low immune function and AIDS. After the infection medical consultation, in view of the patient's condition, immediately for his plasma HIV nucleic acid testing, the viral load of up to 42969 copies / ml. The patient was diagnosed with HIV antibody-negative AIDS partner KS 10 days after he was admitted to hospital. Although the patient received active anti-infection treatment and chemotherapy for KS, the disease has progressed to the end of AIDS, died two weeks after diagnosis.
, KS is a common opportunity tumor in HIV/AIDS patients and a manifestation of the progress of HIV/AIDS to its final stage, according to experts. According to literature, the patient is the world's first HIV antibody-negative AIDS combined lung KS found in adults, the United Kingdom has reported a case of child patients. Zhang Hong, the first author of the paper and an associate professor of respiratory medicine at Beijing Concord Hospital, believes that Concord Hospital has taken the lead in diagnosing lung KS through pathology in China, which is groundbreaking and helps to raise the awareness of doctors in China about the disease.Li Taisheng, author of the
paper communication and professor of infection medicine at Beijing Concord Hospital, said that in this case, patients in many hospitals in many places to detect HIV antibodies and confirmed tests can not be clearly diagnosed, through nucleic acid testing found that there is a high replication of HIV virus in the patient's body, so as to be diagnosed with advanced AIDS, revealing the important value of HIV nucleic acid testing in AIDS diagnosis.
, is there any need to use nucleic acid testing as a screening tool for HIV infection? Li Taisheng said that the current domestic HIV antibody testing of the fourth generation of kits is very sensitive, has been HIV/AIDS window period from the original 3 months to 3 weeks. Due to technical threshold and cost issues, nucleic acid testing is not recommended as a routine screening and diagnosis of HIV/AIDS, but for people with early HIV infection but in the antibody examination "window period", clinically highly suspected of advanced AIDS, but antibody test negative or immunoprotein imprinting test uncertain cases recommended to use, the recommendation has been written by the Chinese Medical Association infected disease branch of the AIDS team in the 2015 edition of the "China AIDS Clinic Guide." (Source: Science Network Zhang Siwei Duan Wenli)