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Apolipoprotein E ( ApoE ) is one of the most abundant apolipoproteins in the brain and the greatest risk factor for Alzheimer's disease, but the pathogenic mechanism has remained unclear
.
On January 26, 2021, Liu Qiang's team from the University of Science and Technology of China published a research paper titled " Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory " in the journal Neuron , revealing the effect of ApoE on neuronal cholesterol The mechanism of metabolic reprogramming and the impact of this metabolic regulation on neuronal function, especially learning and memory processes, also revealed a new mechanism by which ApoE4 causes Alzheimer's disease .
The study first found that ApoE derived from glial cells significantly inhibited key enzymes in the cholesterol synthesis pathway in neurons, thereby inhibiting the synthesis and metabolism of cholesterol in neurons
.
ApoE significantly accumulates acetyl-CoA, the precursor of cholesterol synthesis, by inhibiting the synthesis of cholesterol
This study revealed for the first time a new function of ApoE in the brain, elucidated a new mechanism by which glial cell-derived ApoE affects learning and memory by regulating neuronal lipid metabolism and epigenetic processes, and also explained how ApoE4 acts as an Alzheimer's The high-risk factors of Alzheimer's disease are involved in the disease process, which is of great significance for the in-depth understanding of the pathogenesis of Alzheimer's disease
.
Postdoctoral fellows Li Weihui and Zhang Juan in Liu Qiang's research group are the first authors of this paper , and Professor Liu Qiang is the corresponding author
.
The research was supported by the Ministry of Science and Technology, the Chinese Academy of Sciences, and the National Natural Science Foundation of China, as well as by the Natural Science Foundation of Anhui Province and the University of Science and Technology of China
Original link:
https://
Department of Life Science and Medicine, Liu Qiang Laboratory, University of Science and Technology of China , Hefei National Research Center for Microscale Matter Science, Department of Scientific Research
