China urgently needs new drugs for diabetic foot ulcers

China's indigenous diabetic foot ulcer (DFU) patient population of nearly 10 million, disability, high death rate, social and economic burden is serious, the situation has been very seriousHowever, limited by medical personnel, beds and other hardware resources, coupled with the current treatment of poor results, the vast majority of patients can not be fully and effective treatmentClinically eager to have high healing rate, fast healing rate, low recurrence rate, cost-effective, easy-to-use new products appeardiabetic Foot Ulcer (DFU) is one of the leading causes of disability and death in diabetic patients, and the lack of adequate medical resources and effective medicines leads to poor prognosis and even higher clinical fatality and disability rates than most cancersMore than 85% of diabetics amputate their limbs as a result of the DFU, which puts a more serious treatment and economic burden on both patients and societyAs one of the most urgent unmet needs in the field of diabetes, the disease deserves great attentionChina's local diabetes foot situation has been very serious,the vast majority of patients treatment needs are urgent
China's DFU patients are huge, the death and disability rate is high: in the past 30 years, the prevalence of diabetes in China has soared from an average of 0.67% to 11.6%, of which the prevalence of diabetic foot ulcers is about 5.5%, which calculates that the number of patients with diabetic foot ulcers in China is close to 10 million peopleThe annual mortality rate for DFU patients is as high as 11% and that of amputees is as high as 22%China's DFU has created a serious economic and social burden: in 2017 the global diabetes medical costs amounted to $727 billion, and China accounted for $110 billionAbout 30-40 per cent of these are spent on treatment for diabetic foot, more than $30 billionChina's 2004 multi-center survey showed that the total cost of DFU patients was 14,906 yuan, and in 2012 the multi-center survey showed that the average daily hospital cost of DFU patients nearly doubled compared to 2004 (955 to 589 yuan)The 2010 Multi-Center Diabetes Amputation Rate Survey showed that patients with more than 20 years of illness had the longest number of hospital stays (42 d) and the highest cost of hospitalization (34,253)for patients and for patients: More than 85% of diabetics amputate their limbs due to DFU, which causes amputation due to ineffective or delayed treatment, resulting in loss of lifefor families: at the same time, DFU patients are sick, family care, huge medical costs, a sharp drop in labor income, resulting in a heavy burden on the familyfor health care workers: doctors need a long time to dfu diagnosis and treatment, at the same time consultation multidisciplinary (MDT) joint diagnosis and treatment, the healing process variables, resulting in a continuing burden on physicians, hospitals medical resources, diabetic foot patients difficult to get adequate and effective treatment
China's DFU bed shortage, patient treatment time is seriously inadequate: the latest Health and Wellness Commission health statistics bulletin shows that China's hospital bed utilization rate of 83.6%, the average hospital discharge disadmission days of 9.1 days DFU patients are hospitalized for approximately 18 days However, the average healing time of ulcer wounds in diabetic foot patients is about 113 days, and the median healing time is 75.5 days Diabetic foot patient ulcer wound healing time is much longer than the actual hospital time, on the one hand, patients need to face discharge when the wound does not reach the healing standard, even when discharged from the hospital wound still needs to be discharged from the hospital, but also to face ulcer cure more than 31% of the recurrence rate, the patient is physically and mentally exhausted; the current lack of effective drugs, patients treatment results are not good: at present, the current clinical treatment of diabetic foot ulcer first through wound clean-up surgery to remove rotting meat, necrosis tissue and control infection, and then comprehensive treatment of internal surgery, accelerate wound healing, repair the wound Physical clean-up is the basis of wound treatment, when physical clean-up is not suitable, you can choose self-soluble clean-up, enzymatic clean-up, traditional dressing clean-up and aphid-based and other kinds of clean-up the healing rate of these clean-up seuplet is limited and still needs about half a year At the same time, the new treatment plan represented by biologics, more need to be treated in the hospital at the same time also need to stay for a period of time, and can not significantly shorten the length of hospitalization clinical urgent need for more effective, can significantly shorten the treatment cycle, and easy to apply the emergence of new drugs
although there are many current treatment of diabetic foot, but because of the complex mechanism of diabetes foot, existing treatment methods can not make patients get full treatment, let alone completely solve this clinical problem, the future needs to constantly explore new drugs and treatment methods, especially with high healing rate, rapid healing rate, low recurrence rate, cost-effective, easy-to-use new products In order to further improve the survival rate and quality of life of diabeticpatients, for the benefit of society References: Zhang P, Lu J, Jing Y, et al Global Fundsy of Diabetic Foot Ulceration: A System Review and Meta-Analysis Annals of Medicine, 2016, 49 (2): 1-21.
The Chinese Medical Association Diabetes Credit Association China Diabetes Foot Control Guide (2019 edition) Chinese Journal of Diabetes 2019, 11 (2): 92-108.
2019 China's health and health development statistics bulletin, ban, Ran Xing, Yang Chuan, etc some provinces and cities in China, diabetes foot disease clinical data and hospitalization costs comparison Chinese Journal of Diabetes, 2014,6 (7): 499⁃503.
Smith-Str?m H, Iversen MM, Igland J, et al Severity and of the time-of-the-time -diabetic ulcer (DFU) before seeking care as sgors of the days: aretrospective cohort study PLoSOne 2017;12 (5): e0177176 Published 2017 May 12.
Wang Wei, Ran Xing China's diabetes foot management, where is the road? Chinese Journal of Diabetes, 2018, 10 (7) : 441-444.