ChinaMAP study data: Northerners drink more alcohol than southerners.

Source: Mr. Sai wrote. Qin Fangfei metabolic-related diseases, such as type 2 diabetes, obesity and so on, have become a growing human public health problem, affecting the global morbidity and mortality rate.
many common metabolic defects and diseases are caused by genetic mutations in the population, the establishment of a gene pool of genetic information related to metabolic diseases is critical for us to understand these diseases, advance drug development, and precision medicine.
, April 30, 2020, cell research published a long article entitled "The ChinaMAP analytics of the whole body genome sequences in 10,588 individuals", the first report on China's genomics database China Metabolic Analysis Program China Analytics Project.
ChinaMAP national metabolic disease clinical medical research center (Shanghai) based on Shanghai Jiaotong University School of Medicine affiliated with Ruijin Hospital led a number of nationwide cohort research, mainly used for comprehensive analysis of the genetic heterogeneity between The Han Chinese and other major ethnic minorities in China, as well as their contribution to metabolic diseases, so as to obtain biomedical-related quantitative characteristics.
ChinaMAP national metabolic disease clinical medical research center (Shanghai) based on Shanghai Jiaotong University School of Medicine affiliated with Ruijin Hospital led a number of nationwide cohort research, mainly used for comprehensive analysis of the genetic heterogeneity between The Han Chinese and other major ethnic minorities in China, as well as their contribution to metabolic diseases, so as to obtain biomedical-related quantitative characteristics.
currently, ChinaMAP integrates 150,000 participants in noncommunicable disease surveillance, 250,000 participants in the diabetes cancer risk assessment, and 50,000 participants in the Shanghai urbanization risk study.
researchers randomly selected 27 provinces and eight ethnic groups: Han, Hui, Manchu, Miao, Mongolian, Yi, Tibetan and Zhuang, and analyzed GWAS data from 10,588 participants. The average age of the participants in the
was 54 years, with 64.8 per cent female.
information on the location, comments, frequency, and data quality of all variations in the ChinaMAP database can be searched on the website of the National Centre for Clinical Medicine of Metabolic Diseases.
with the management and approval of the Ministry of Science and Technology's regulations on the management of human genetic resources, researchers can further cooperate with the ChinaMAP research team.
data analysis shows that drinking and drinking coffee are the most common health-related eating habits.
by analyzing the genetic polymorphisms of ALDH2 (rs671) and ADH1B (rs1229984 and rs2066702) associated with ethanol metabolism and dependence, it was found that the general rate of ethanol removal in Chinese was lower than in Europe and Africa.
, although Chinese wine culture is prevalent, it is not as good as others in terms of drinking potential.
the gene ALDH2 rs671 associated with alcohol blush in Asians, 4.50% of pure sons in Asians and 34.27% of hemica, with a higher risk of acetaldehyde enrichment and esophageal cancer.
from the geographical distribution point of view, in China, northerners have stronger ethanol metabolism than southerners, ethnic minorities such as Tibetans, Mongolians, Yi people, etc. ranked first, while Lingnan Han (Guangdong Province), southeast Han (Fujian Province) basically bottom.
as far as the metabolism of caffeine, there is no preference in people in different parts of the country and at home, that is, there is no difference in the genes that regulate caffeine metabolism.
's preference for coffee is the habit of the day after nature to cultivate, but whether love to drink, or do not drink coffee, metabolic ability is not much difference.
in addition, on February 24, 2020, at the height of the new crown outbreak, the study analyzed the gene heterogeneity analysis of the receptor human ACE2 of the new coronavirus, published in the journal Cell Discovery, and found that there is no evidence that the naturally occurring neo-coronavirus S protein cannot bind to the ACE2 mutant, and that the expression of ACE2 in East Asian human tissues is high, proving that East Asians may be more susceptible.
is still controversial about this conclusion, after Zhong Nanshan, Qian Wenfeng, Cai Guoshuo and other research teams said that there was no difference in the expression of ACE2 receptors on the cell surface of different ethnic groups (Asians and Europeans), but smokers, especially those with a history of smoking, had high levels of ACE2 expression in the lungs and may have more severe symptoms when infected with the new coronavirus.
in short, the genetic database on metabolic diseases has previously originated mainly in Europe, and large-scale data research on East Asians is lacking, and ChinaMAP has established a high-quality Chinese group database that can provide a basis for disease mechanism research, risk assessment, disease prevention, genetic counselling and public health management.
ChinaMAP's accurate genetic structure analysis of Han and ethnic minority groups also provides reference data for the study of accurate genomics in Chinese groups.
Source: Mr. Sai.