China's domestic vaccine market: 45 enterprises, 63 kinds of vaccines

President Xi and Premier Li Keqiang both gave important instructions on the Changchun Changsheng vaccine incident The vaccine is of great importance President Xi and Premier Li Keqiang both instructed relevant departments to conduct thorough investigation and determined to improve the vaccine management system with the "strong medicine to eliminate waste and curettage the bone" Premier Li Keqiang asked for a clear explanation to the people of the whole country I don't want to make any comments on Changchun Changsheng incident here, but make a general inventory of the vaccines that have been listed in China at present At present, according to the statistics of evaluate Pharma, the global vaccine market scale in 2017 is close to 30 billion US dollars, among which GSK, MSD Sanofi and Pfizer are the "four kings" in the vaccine market, and the cumulative market share of the four is as high as 90.1% In China, the batch issuance system is implemented for vaccine sales CFDA and 7 provincial drug inspection institutions authorized to undertake the batch issuance of biological products jointly promote the batch issuance The situation is roughly as follows: 1 As a whole, domestic vaccines account for more than 90% of the main vaccines on the market (as shown in the figure below); the issuance of domestic and imported vaccines from 2012 to 2017; 2 There are 20 types of class I vaccines on the market in 2017, state-owned enterprises are still the main suppliers of class I vaccines, while private enterprises mainly supply class II vaccines Inventory of vaccines already on the market: 63 kinds of vaccines from 45 enterprises have been sorted out According to the 2017 annual report of biological products batch issued by CFDA, the general situation of vaccine market in China is briefly introduced 1 Statistics of vaccines already on the market: 63 kinds of vaccines account for the largest proportion of influenza vaccines According to the public information, the author has sorted out and obtained At present, there are 63 kinds of vaccines approved for the market in China, including 13% of influenza vaccines, 11% of meningococcal vaccines, 11% of rabies vaccines and 10% of hepatitis vaccines 2 Statistics of 45 vaccine manufacturers: China Biotechnology Co., Ltd has the largest number of varieties from the perspective of enterprises, regardless of the number of batches issued The author has obtained the above table based on the number of varieties Among them, China Biotechnology Co., Ltd has listed 98 varieties, Beijing Institute of biological products, Ministry of health 11 varieties, 10 varieties of Changsheng biology and 10 varieties of Sanofi 3 Data of batch issuance in 2017: the annual report of batch issuance of biological products in 2017 shows that the largest number of batch issuance of oral type I and III live attenuated polio vaccine (human diploid cells) was 162083400 in 2017 1 In general, domestic vaccines account for more than 90% of the vaccines on the market; however, some domestic vaccines still have no production capacity and are imported, such as the combined vaccine of adsorbing acellular leukocyte free inactivated poliomyelitis and Haemophilus influenzae type B (combined), 13 Pneumococcal polysaccharide conjugate vaccine, bivalent human papillomavirus adsorption vaccine, bivalent human papillomavirus vaccine (Saccharomyces cerevisiae), etc.