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    Home > Medical News > Latest Medical News > China's first panorama of the molecular pathology of protein molecules of the new crown deceased

    China's first panorama of the molecular pathology of protein molecules of the new crown deceased

    • Last Update: 2021-01-22
    • Source: Internet
    • Author: User
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    scientists' research on the new coronavirus and pathogenicity is continuing to deepen, and the molecular dimension of organ damage in patients with neo-corona pneumonia is gradually being lifted.
    January 9, Beijing time, Cell, a leading academic journal, published a study online by researchers from the School of Life Sciences of West Lake University and Concord Hospital affiliated with Tongji Medical College of Huahua University of Science and Technology, entitled "Multi-organ Proteomic Landscape of COVID-19 Autopsies". The study provided a panoramic view of the molecular pathology of proteins in multi-organ tissue samples of patients who died of neocytosis in early 2020, which helped to better understand the new coronary death pathogenesies and to provide accurate interventional treatment to patients.
    This is the first time in the world from the protein molecular level, the new coronavirus infection of the human body after a number of key organs of the response to a detailed and systematic analysis, for clinicians and researchers to develop treatment plans, the development of new drugs and treatments provide clues and evidence.
    Guo Tiannan
    of West Lake University, Professor Hu Yu of Wuhan Concord Hospital, Professor Xia Jiahong and Associate Researcher Zhu Yi of West Lake University are co-authors of the paper. Professor Yan Xiu of Wuhan Concord Hospital, Dr. Qian Yujia and Sun Rui of Guo Tiannan Group, Huang Bo and Dong Xiaochuan of Concord Hospital, Xiao Wei, Research Assistant of Guo Tiannan Research Group, and Zhang Qiushi of West Lake Omi (Hangzhou) Biotech Co., Ltd. are co-authors.
    According to Guo Tiannan's lab, the study is the equivalent of the team zooming in tens of thousands of times on changes in cellular tissue after a new crown infection that doctors see under a microscope, reaching the protein molecular level, to "see" which molecule changes cause lesions and failure of human organs.
    the paper, the team collected 144 tissue samples from seven organs, including the lungs, spleen, liver, heart, kidneys, thyroid gland and testicles, of 19 patients who died from COVID-19. All of the 19 COVID-19 patients died of neo-coronary pneumonia or respiratory failure, including 7 cases of advanced multi-organ dysfunction syndrome (MODS). They also collected 74 controlled tissue samples from 56 non-COVID-19 patients.
    Through the pathological examination under the mirror, the research team found that the patient's lungs appear diffuse alva damage, pulmonary fibrosis, neitrophic granulocyte immersion and thrombosis and other pathological changes, spleen white myelin atrophy, liver atrophy and some cases of infarction, heart myocardial edema and interstitial lymphocyte immersion phenomenon, kidneys found acute renal small tube injury.
    Based on mass spectrometry data sampling and histological data analysis based on high-pressure cycling technology (PCT) and TMT markers combined with bird gun proteomics technology, the team identified a total of 11,394 personal source protein molecules and graphed a panoramic view of multi-organ protein molecules in patients with neo-critical deaths. A comparison with a controlled tissue sample from non-neo-crown patients showed that 5,336 proteins in the sample group of patients who died had changed.
    of these seven organ tissues, the team did not identify significantly altered proteins in the red myelin of the spleen, while the liver had the highest number of protein changes (N-1970). This, the team believes, means that liver damage may be greater in patients who die from neo-crown pneumonia.
    It is worth mentioning that during the invasion of the human body by the new coronavirus, the viral ligand angiotensin-converting enzyme 2 (ACE2 protein, a protein that mediates blood pressure in the body) is a subject that binds to the invading "key" hedgehog protein. The molecular study by the team found that the amount of ACE2 protein was not significantly different from that of non-neo crown patients in the various organs of new crown patients. But another protein, the tissue protease L (CTSL), that helps the virus enter cells, has increased significantly in the lungs of patients with new crowns.
    study suggests that the expression level of ACE2 has not changed in patients with neo-coronavirus, which is only a channel for new coronavirus to enter the human body, but ctSL may be a potential therapeutic target to block virus invasion.
    team further conducted a systematic comparative study of physiological function, pathological morphology and proteomics of various organs and found changes in multiple lung proteins, including those associated with viral proliferation, involved in the pathological process of pulmonary fibrosis, and degradation of viral limiting factors. Proteomics also showed that the lungs and spleen showed adaptive immune response inhibition with the increase of immune checkpoint protein and the reduction of T-cell-rich protein as molecular characteristics, and the decrease of lymphocytes such as T and B of the spleen also confirmed the molecular characteristics.
    addition, although only the lungs have substantial fibrosis lesions in clinical pathology, proteomics results show that organs such as the liver and kidneys also have precursor to tissue fibrosis. This suggests that prevention and early intervention of the possible sequelae of "multi-organ fibrosis" is needed for patients with critical conditions who have recovered.
    it is worth mentioning that in this pandemic, male infection and mortality rates are higher, the new coronavirus damage to male reproductive function and other research views have also been of great concern. Guo Tiannan et al. also found 10 proteins that significantly altered testicular tissue in patients with new crowns, and their function was closely related to cholesterol synthesis inhibition, decreased sperm activity, and reduced Leydig cell-specific markers. Among them, Leydig cells are closely related to male male hormone synthesis and secretion, suggesting that the fertility of male newly crowned patients may be affected.
    team also cautioned of limitations, based on tissue samples from patients with neo-crown deaths, but whether the same changes would occur in patients with mild and severe illnesses and whether such changes were reversible needed further study.
    paper link:
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