Chinese Academy of Sciences scholar Cell’s latest article: How disease-resistant bodies protect plants from pathogens

In plants, disease-resistant proteins are the main immune receptors, which can sense pathogens and pests and trigger powerful defense responses

To this end, researchers from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences Zhou Jianmin, Chen Yuhang, and He Kangmin, in cooperation with Professor Chai Jijie of Tsinghua University, used the most advanced electrophysiology and single-molecule imaging technology to study its molecular mechanism, and finally discovered ZAR1 disease-resistant bodies can activate plant immunity

This latest discovery was published in Cell Magazine on May 12

In the latest study, the researchers found that ZAR1 anti-disease bodies are cation-selective and calcium-permeable ion channels through electrophysiological studies based on Xenopus oocytes and planar lipid bilayers

The formation of ZAR1 disease-resistant bodies in plant cells triggers a continuous influx of calcium ions and subsequent immune signal events that lead to cell death.

These results point to the conclusion that the calcium signal triggered by the ZAR1 channel initiates immune activation, thereby providing vital insights for the work of the plant immune system

Disease-resistant proteins are the largest family of plant immune receptors, which can protect crops from a variety of pathogens and pests (including viruses, bacteria, fungi, oomycetes, nematodes, insects and parasitic weeds), and are important in agriculture Meaning

The findings of this study also revealed the precise biochemical functions of many disease-resistant proteins and proposed new methods for controlling crop diseases and insect pests

Cell commented that this work "provides important findings that will change our perception of ETI-triggered cell death

(Biology: Wanwen)

Original title:

The ZAR1 resistosome is a calcium-permeable channel triggering plant immune signaling

http://dx.