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    Home > Biochemistry News > Biotechnology News > Chinese Academy of Sciences scholar eLife published a paper: Establishing a new type of venous thrombosis disease model

    Chinese Academy of Sciences scholar eLife published a paper: Establishing a new type of venous thrombosis disease model

    • Last Update: 2021-11-15
    • Source: Internet
    • Author: User
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    Mature red blood cells are rich in hemoglobin, with a carry oxygen function, critical to maintaining the body's homeostasis 1
    .
    Red blood cell defects can cause a variety of diseases, including hemoglobin anemia, red blood cell lytic anemia, and thrombosis.


    2-4


    On October 26, 2021, the research team of Feng Liu from the Institute of Zoology, Chinese Academy of Sciences published a paper entitled The chromatin-remodeling enzyme Smarca5 regulates erythrocyte aggregation via Keap1-Nrf2 signaling in eLife magazine
    .
    The work found that the red blood cells of the zebrafish smarca5 mutant aggregated abnormally and deposited in the tail vein


    .


    The researchers first started from the phenotype of abnormal aggregation of red blood cells of the smarca5 mutant, to confirm the phenotype and study the mechanism of the thrombotic disease model
    .
    When the smarca5 mutant developed to the second day after fertilization, blood cells accumulated abnormally and deposited in the tail vein


    .


    Chromatin remodeling factors Smarca5 nucleosome spacing may be adjusted, thereby affecting gene transcription 9
    .
    In order to explore the effect of smarca5 deletion on the accessibility of red blood cell transcriptome and chromatin, the researchers used RNA-seq and ATAC-seq to analyze smarca5 mutant and control embryonic red blood cells


    .


    In summary, this study found the phenotype of abnormal red blood cell aggregation in smarca5 mutants for the first time , and preliminarily analyzed the mechanism of smarca5 regulating red blood cell aggregation.
    At the same time, the researchers established a new venous thrombosis disease model.
    As a thrombotic disease model and used in drug screening and other clinical translational research to lay the foundation


    .


    Researcher Liu Feng from the Institute of Zoology, Chinese Academy of Sciences is the corresponding author of the thesis, Ding Yanyan, a postdoctoral fellow in the Biological Island Laboratory, Li Yuzhe, a doctoral candidate at Tsinghua University, and Zhao Ziqian, a graduate student from the Institute of Zoology, Chinese Academy of Sciences, are the co-first authors of the paper.
    Professor Zhang Qiangfeng from Tsinghua University participated in this paper.


    Work


    Article link: https://elifesciences.


    Pictured : Abnormal aggregation of red blood cells in the smarca5 mutant

    Picture: Smarca5 regulates red blood cell aggregation by regulating the Keap1-Nrf2 signaling pathway

    references

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