Chinese Academy of Sciences scholar Protein&Cell published a paper: Single-cell transcriptome map of primate hippocampus senescence

The hippocampus, as an important part of the brain, plays a vital role in learning and memory

On May 30, Liu Guanghui's research group and Qu Jing's research group from the Institute of Zoology, Chinese Academy of Sciences collaborated with Wang Si's research group at Xuanwu Hospital of Capital Medical University to publish a study titled "Single-nucleus transcriptomic landscape of primate hippocampal aging" in Protein&Cell.

In this study, the researchers obtained hippocampal tissues of young and old cynomolgus monkeys.

By drawing pseudo-time curves of neurogenesis trajectories and gene expression dynamics analysis, the researchers found that neurogenesis in the aged hippocampus tissue is mainly reflected in the decline in the proliferation of transiently expanded progenitor cells in the early stage and the impairment of neuronal function in the late stage

The study reported the first high-precision mononuclear transcriptome map of primate hippocampal aging in the world, systematically analyzed the aging changes of multiple cell types in primate hippocampus tissue, and revealed the main molecular characteristics of hippocampal aging , Including changes in cell internal factors and external microenvironmental factors that are damaged by neurogenesis

The relevant data has been uploaded to the Aging Atlas ( https://bigd.

The research was conducted by the Institute of Zoology, Chinese Academy of Sciences, the National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, the Institute of Stem Cell and Regenerative Medicine Innovation, Chinese Academy of Sciences, Beijing Institute of Genomics, Chinese Academy of Sciences, Peking University Third Hospital, Beijing Stem Cell and Regenerative Medicine Research This is done in cooperation with institutions such as the hospital

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