Paclitaxel (Taxol) is a first-line treatment for tumors such as ovarian cancer, breast cancer and non-small cell lung cancer
From a structural point of view, paclitaxel contains 11 chiral centers and has a highly oxidized and complex [6-8-6] bridged ring system.
The team of Professor Li Chuangchuang of Southern University of Science and Technology has been committed to the research of the total synthesis of natural products with high tension bridge ring system, developed a new synthesis strategy, and completed the asymmetric total synthesis of paclitaxel
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