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Prenatal and preimplantation genetic diagnosis prevents intergenerational transmission
"Mitochondrial replacement therapy is a controversial field," said
Mitochondrial disease
About 1 in 5,000 children get sick
Spindle transfer
Shang and her colleagues studied one of three main types of mitochondrial replacement therapies: the safety of
The authors rigorously screened 1,397 cells (768 cells from 23 ST blastocysts and 629 cells from 22 intracytoplasmic sperm injection (ICSI) control blastocysts) from 46 blastocysts in 2 experimental groups (5 days after fertilization) for subsequent analysis
Dietrich Egli, a stem cell biologist at Columbia University in New York, said: "This is the first [study]
Min Jiang, a mitochondrial biologist at WestLake University in Hangzhou, China, says the long-term effects of mitochondrial replacement therapy are unclear
Research regulation
Only a handful of countries, including the UK and Australia, have approved mitochondrial replacement therapy
Shang said the team plans to conduct clinical trials
Egli believes that studies on the safety of spindle transfer will provide important evidence to help regulators in countries that do not allow spindle transfer to assess its safety and effectiveness