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    Home > Biochemistry News > Biotechnology News > Chinese scholars confirmed that spindle transplantation containing three human DNA is basically normal single-cell multi-omics analysis

    Chinese scholars confirmed that spindle transplantation containing three human DNA is basically normal single-cell multi-omics analysis

    • Last Update: 2022-09-14
    • Source: Internet
    • Author: User
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    The mitochondria that provide energy to the cell are indispensable organelles for most eukaryotic cells and are the only organelles in human cells that have their own genetic material, including 37 genes—13 encoding mitochondrial proteins and 24 producing non-coding RNAs


    Prenatal and preimplantation genetic diagnosis prevents intergenerational transmission


    "Mitochondrial replacement therapy is a controversial field," said


    Mitochondrial disease

    About 1 in 5,000 children get sick


    Spindle transfer

    Shang and her colleagues studied one of three main types of mitochondrial replacement therapies: the safety of


    The authors rigorously screened 1,397 cells (768 cells from 23 ST blastocysts and 629 cells from 22 intracytoplasmic sperm injection (ICSI) control blastocysts) from 46 blastocysts in 2 experimental groups (5 days after fertilization) for subsequent analysis


    Dietrich Egli, a stem cell biologist at Columbia University in New York, said: "This is the first [study]


    Min Jiang, a mitochondrial biologist at WestLake University in Hangzhou, China, says the long-term effects of mitochondrial replacement therapy are unclear


    Research regulation

    Only a handful of countries, including the UK and Australia, have approved mitochondrial replacement therapy


    Shang said the team plans to conduct clinical trials


    Egli believes that studies on the safety of spindle transfer will provide important evidence to help regulators in countries that do not allow spindle transfer to assess its safety and effectiveness


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