Chinese scholars have discovered the apoptosis mechanism of inflammatory macrophages

macrophages are an important part of the innate immune response, and zinc plays a key role in macrophage apoptosis. Wang Fu team at Zhejiang University School of Medicine and Yan Junxia team discovered zinc ion transport proteins that regulate macrophage apoptosis, and found apoptosis mechanisms for macrophages in inflammatory states. The papers are published in internationally renowned journals
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team identified the metal ion transport protein SLC39A10 mediated macrophage zinc ion intake through the gene knock-out mouse model, and found that in the inflammatory state, the mortality rate of gene knock-out mice decreased significantly, liver damage and blood inflammatory factor levels were significantly reduced. Further experimental tests have found that the significant decrease in the number of macrophages is due to apoptosis due to the lack of zinc ions.
researchers say macrophages play an important role in maintaining the function of tissue organs, identifying and removing pathogens, and repairing damaged organs. The results will provide new ideas for the prevention and treatment of diseases such as inflammation and sepsis. (Source: Xinhua News Agency, Zhu Han)