Chinese scholars have found that intestinal microbial disorders are linked to severe depression, science advances

Severe depression (MDD) is a common mental illness that manifests it as one or more depressive states, but has no history of severe mania, mixed mania, and mild mania.
, about 350 million people worldwide suffer from depression, and 15 percent are suicidal.
the pathogenesis of MDD is not clear and the lack of biomarkers leads to a higher rate of misdiagnosis.
, it is important to understand and determine the molecular basis and biomarkers of MDD.
the study included 311 subjects, including 156 MDD patients and 156 general subjects, and collected 311 stool samples for comprehensive analysis of enterovirus, bacterial microorganisms and fecal metabolism.
, the researchers conducted a large-scale gas chromatography-mass spectromety analysis of the samples to learn more about them.
Researchers who identified MDD and HC strains, bacterial species, and fecal metabolites found that three phages, 47 bacteria, and 50 fecal metabolites increased or decreased significantly in MDD patients compared to the average subject.
main features in patients with MDD are an increase in the abundance of the genus Bacteroides and a decrease in the abundance of the Blautia and Eubacterium genus.
Bacteroides may lead to increased levels of cytokines and associated inflammation in patients with MDD, the researchers said.
addition, the researchers found that disturbed microbial genes and fecal metabolites were always associated with the metabolism of amino acids (γ-amino butyric acids, phenylalanine and tryptophan).
this series of marker indicators to effectively distinguish MDD patients.
past, MDD patients were diagnosed by talking, and in the future it may be lying about changes in gut microbes to diagnose MDD patients.
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