Chinese scholars have found that the new recombinant swine flu virus has pandemic potential.

As of June 30, the new coronavirus has infected more than 10 million people worldwidePreviously, scholars have suggested that the new crown epidemic will last 1-2 yearsIn the new crown epidemic continues to develop today, the world can not afford another epidemicHowever, a recent study showed that a virus that could lead to the next pandemic has been found in pigslocal time on June 29, PNAS published an online study by Professor Liu Jinhua of China Agricultural University and Gao Fu, director of the China Center for Disease Control and Prevention, as the author of the newsletterThe report suggests that a Type G4 gene,h1N1 influenza virus, which is produced by three different genealogical viruses "re-run" (exchange genes), is found in China and that the virus, which is generally immune to humans, may lead to an increased risk of human-to-human transmissionSince the emergence of the H1N1 virus in 2009, several countries have realized the importance of continuous monitoring of swine flu viruses (siv) and assessing their potential impact on zoonotic diseases in preventing pandemicsbetween 2011 and 2018, researchers actively monitored normal pigs in slaughterhouses in 10 provinces in China, where they collected 29,918 nasal swabs and isolated 136 influenza viruses with a separation rate of 0.45 percentDuring the same period, researchers isolated 43 influenza viruses from sick pigs in a laboratory at the Agricultural University of China, with a separation rate of 4.23%genetic sequencing of the virus, the researchers found that the vast majority of the virus escant4 (G4) recombinant Eurasian poultry influenza (EA) H1N1 virus (EA) H1N1 virus (G4 virus) or related G-series virus, and the G4 strain has been dominant since 2016, accounting for the vast majority in 2018To assess the potential of zoonotic disease in the G4 strain, the researchers selected four representative strains for further biological identification and used two G1 strains as referenceIt was found that the G4 strain was able to combine with human SA alpha2,6Gal receptors with high affinity, which is a prerequisite for infection of human cells, and that the virus can be replicated efficiently in the skin cells of the popular tract, the G4 virus is also susceptible to infection and spread between ferrets, a popular animal model for the study of human influenzaAt the same time, the low antigen cross-reaction of the human influenza vaccine strain with the G4 recombinant EA H1N1 virus shows that existing population immunity does not provide protection against the G4 virusIn a family survey, researchers found that 4.4 percent of 230 people had antibodies to the G4 strain, a rate that more than doubled among people working in pig farmsOn the same day, in an opinion piece published in Science, Edward Holmes, an evolutionary biologist at the University of Sydney, said, "The current data suggest that this appears to be a swine flu virus that is about to appear in humans." "Of course, there are 500 million pigs in China, and in this respect, the sample size of this study is not large enough, but it just gives people a small understanding of the swine flu virusSun Honglei, a report's lead author and an associate researcher in the Department of Preventive Veterinary Medicine at the School of Animal Medicine at The Agricultural University of China, believes that the G4 virus contains the 2009 H1N1 pandemic and may therefore promote the virus's adaptation, leading to human-to-human transmission "Not only does there need to be enhanced detection of the swine flu virus in China, but it makes sense to develop a vaccine against G4 for pigs and humans." .