The clinical application of toxic traditional Chinese medicine has received extensive attention, and the toxicity of traditional Chinese medicine has become one of the hot issues affecting the development of the traditional Chinese medicine industry
The team’s recent study found that aristolochic acid, a toxic component of traditional Chinese medicine, can self-assemble with berberine to form a stable supramolecular structure during the decoction process, which can block the toxic groups of aristolochic acid, nitro and hydroxyl.
Figure 1 Aristolochic acid (AA) and berberine (Ber) self-assemble to form "AB" linear supramolecules, block the toxic group of AA, inhibit the imbalance of intestinal flora, and reduce acute nephrotoxicity
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