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    Home > Biochemistry News > Biotechnology News > Chinese scholars have made progress in the controllable synthesis of organic fluorine compounds

    Chinese scholars have made progress in the controllable synthesis of organic fluorine compounds

    • Last Update: 2021-08-28
    • Source: Internet
    • Author: User
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    With funding from the National Natural Science Foundation of China (project numbers: 21672195, 21702201, 21971226), Wang Yifeng's research team from the University of Science and Technology of China and Hefei National Research Center for Microscale Physical Science collaborated with the theoretical computational chemist K.


    Houk's team , Has made important progress in the field of controllable synthesis of organic fluorine compounds


    Organic fluorine compounds are widely used in the fields of life sciences and material sciences due to their unique alkalinity, lipophilicity, oxidation resistance and high physical and chemical stability.
    The efficient synthesis of such compounds is an important research in the field of chemistry.
    Direction
    .


    Starting from abundant sources of trifluoromethyl compounds, obtaining functional fluorine-containing molecules through continuous and controllable defluorination conversion is one of the approaches that has attracted much attention


    The team of Professor Yifeng Wang of the University of Science and Technology of China and Professor K.
    Houk's team were inspired by the spin-center shift (SCS) mechanism in biosynthesis and designed a new strategy for breaking the carbon-fluorine bond , Realizing the stepwise controllable functionalized conversion of trifluoromethyl defluorination
    .


    This strategy starts with cheap and easily available trifluoroacetic acid derivatives, uses the difference in the reaction performance of 4-dimethylaminopyridine-boron radicals with trifluoro, difluoro and monofluoroacetyl compounds, based on the SCS mechanism, to achieve trifluoroethane The stepwise controllable defluorination functionalization reaction of amide and trifluoroacetate; the chemical selective construction of difluoro and monofluoro compounds is achieved through two continuous and independent processes (Figure 1)


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