Supported by the National Natural Science Foundation of China (approval numbers: 81971860, 81772110) and other funds, the team of Wang Jian’an and Xu Yinchuan of the Department of Cardiovascular Medicine, the Second Affiliated Hospital of Zhejiang University School of Medicine, and the team of Zhang Zhaocai of the Department of Critical Care Medicine, induced cardiac function in sepsis.
Sepsis is a systemic inflammatory response syndrome caused by pathogenic organisms such as bacteria invading the body, which often leads to organ dysfunction.
The research team constructed a mouse model of sepsis-induced cardiac dysfunction by intraperitoneal injection of lipopolysaccharide and cecal ligation and perforation, and used hepatocyte-specific angiotensinogen (AGT) knockout and cardiomyocyte-specific AGT knockout The two transgenic mice confirmed that the down-regulation of liver-derived AGT, rather than the local AGT produced by cardiomyocytes, can reduce the cardiac dysfunction of septic shock mice and prolong their survival time
The study found that AGT derived from hepatocytes regulates the "liver-heart" axis of cardiac dysfunction induced by sepsis through angiotensin II-dependent and independent pathways, and verified the specific knockout of hepatocytes through animal models.
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