Chinese scholars have made progress in the study of the mechanism of fat-brain communication mediating cognitive dysfunction in diabetes

With the support of the National Natural Science Foundation of China (approval number: 82030026, 82100868, 82000775), Professor Bi Yan's team from the Department of Endocrinology, Gulou Hospital, Nanjing University School of Medicine, has made new progress

Using fat grafting and a variety of exosome tracing techniques, the research team found that liver-derived extracellular vesicles (EVs) cannot mediate peripheral tissue and inter-brain communication, and adipose tissue-derived EVs are an important biological medium for forming communication between the two; In insulin-resistant and diabetic states, adipose tissue EVs carry contents miRNAs promote hippocampal synapse loss and cognitive impairment

This study reveals the communication mechanism between adipose tissue and brain organs, elucidates the important role of adipose tissue-derived extracellular vesicles and their contents miRNAs in the occurrence of diabetic cognitive dysfunction, and provides new ideas