Medicine Network January 11 - Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that is more common in women and can cause damage to multiple organs, seriously life-threatening.
the cause of the disease is unknown and there is currently no effective cure.
Reporters learned on the 9th, Shanghai Jiaotong University School of Medicine affiliated Renji Hospital Rheumatology Research Institute Professor Shen Nan team took the lead in the SLE autoimmune disease risk genetic variation and the cause of the link, expounded in the lupus disease in the key path of the key regulatory role of non-coding RNA-related molecular genetic mechanism, for the treatment provides a new direction and target.
their study demonstrated strategies for screening functional disease susceptibility points and functional regulatory components.
studies have shown that genetic and environmental factors are closely related to the onset of SLE, for example, in people with SLE, identical twins are far more likely to develop the disease than identical twins.
Shennan, a professor of genetic research, said that studying the genomic functions that determine genetics would help shed light on the pathogenesis of SLE and develop new prevention and treatment methods.
it is understood that Shennan research team has been focusing on genetic and SLE-related research.
In recent years, using traditional generation sequencing and advanced second-generation sequencing and exon sequencing, researchers have discovered a number of SLE-related disease susceptible genes and locations, and related studies have confirmed SLE's genetic susceptibleness, and has been confirmed and widely concerned by international peers.
Shennan said in an interview that only by determining functional genetic susceptibility points and analyzing the molecular mechanisms in them can we provide new ideas for early detection, early diagnosis and treatment of diseases.
research has always been the hot spot and difficulty in the field of genetics.
is known to account for 99% of non-coding sequences in the human genome.
as part of a non-coding sequence determines which cell the gene can express and the fate of cell differentiation.
lupus genetic susceptible site found in the genetic data is mostly located in the non-coding region, but also in the enhanced sub-region.
researchers used genetics and other multi-group techniques to determine potentially regulated disease susceptibility points, and found that the relevant enhancers finely regulate the expression of lupus-caused genes.
their findings were published online in Nature Communications, an authoritative international journal.
, the study was supported by the National Natural Science Foundation of China, the National Human Genetic Resources Sharing Service Platform, and the Shanghai Key Medical Center.