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Original title: Chinese scientists analyze the rice plague bacteria glycosylation modified protein group diagram and mechanism of action
Recently, the Institute of Plant Protection of the Chinese Academy of Agricultural Sciences, in cooperation with Huahua Agricultural University, Sainsbury's Laboratory in the United Kingdom and other units, took the lead in mapping the rice plague bacteria N-glycosylated modified protein The group diagram, and revealed that N-glycosylation modification participates in the molecular mechanism of plant pathogenic fungal growth and development and pathogenicity, which will provide an important candidate target for the prevention and treatment of rice plague, and also lay a foundation for an in-depth understanding of the pathogenic mechanism of plant pathogenic fungi. The study was published online in Public Library of Science: Pathogens.
, according to Liu Wende researcher, rice plague is a serious threat to the safety of rice production in the world, often local or widespread epidemic, resulting in major losses in agricultural production. Protein N-glycosylation is carried out in the endoscape and goerki, regulating the process of protein folding and transportation of living organisms. However, in plant pathogenic fungi, a large number of proteins modified by N-glycosylation have not been identified, and the molecular mechanisms that regulate the growth and development of pathogens and the pathogenic process are not clear. Using quantitative modification of proteomics, the researchers mapped N-glycosylation modification at a total of 559 of the 355 proteins of the rice pest bacteria, and found that the vast majority of the proteins involved in the endocystral network quality control system were identified as N-glycosylated proteins. In-depth analysis reveals that the key protein coding genes Gls1, Gls2, GTB1 and Cnx1 of the system are very important to the pathogen-infested cycle of mycelium growth, spore development and infested mycelium expansion processes, and Gls1 glyco-based modification regulates its protein stability and internal network positioning, thus affecting the biological function of the endostronic network quality control system.
the study was supported by projects such as the National Natural Science Foundation of China, the Science and Technology Innovation Project of the Chinese Academy of Agricultural Sciences and the Opening Of the National Key Laboratory for Plant Pest Biology.
original link:
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