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| My scientist discovered and named a novel centromere functional protein |
The reporter learned from the University of Science and Technology of China that the team of Yao Xuebiao, Liu Xing, and Liu Dan used the co-evolution strategy of eukaryotic mitosis regulatory network genes and the spatiotemporal proteomics method of organelles to discover and name a novel centromere function.
Protein, Apolo1, and systematically analyzed the biochemical function of Apolo1, and the research results were published online on July 13th in Cellular Communications
.
The precise self-replication of cells is an important part of their life history and an important guarantee for human health
.
In the process of mitosis, the parental genetic information contained in the chromosomes undergoes many complex movements and is equally transmitted to the two daughter cells
The study found that Apolo1 interacts with the PBD domain of PLK1 through its N-terminus, while its C-terminus contains a classic PP1γ phosphatase binding motif
.
Interestingly, the PP1γ binding activity of Apolo1 is regulated by PLK1 kinase phosphorylation
This research work intersects the research fields of functional proteomics and model biology, suggesting the important function of Apolo1 in the maintenance of genome stability and stem cell proliferation
