Chinese scientists find the mechanism by which adipose macrophages cause insulin resistance in fat people

Photo: Science Advancesresearchers found that SBP2 in diet-induced obese mice was inhibited, a phenomenon associated with inflammation of adipose tissueLoss of SBP2 triggers metabolic activation of ATMS, inducing an increase in the amount of reactive oxygen and the number of inflammatory minisomes in the cell, which in this would subsequently lead to local proliferation and leaching of IL-1 beta-associated inflammatory macrophagesresearchers found that specifically knocking out SBP2 in atMs in obese mice can promote insulin resistance by increasing inflammation and expansion of adipose tissueReexpression of SBP2 improves insulin sensitivityfinally, the researchers also found a herbal formula that specifically induces SBP2 to be expressed in ATMs, which can improve insulin sensitivity in experimentsClinical observations show that it can improve hyperglycemia symptoms in diabetic patientstherefore, this study identified SBP2 of ATMs as a potential target for reversing insulin resistance in obese patientsReferences:Yibin Feng et alSBP2 nlyin adipose tissue macrophages drives insulin insulin in obesity Science Advances2019DOI: 10.1126/sciadv.aav0198