Chinese scientists first constructed a mononuclear transcriptome map of primate hippocampus aging

There is an area called the hippocampus deep in our brain

The hippocampus has a complex structure and is composed of highly heterogeneous cells, so it is difficult to accurately reveal the molecular regulatory network of various cell types involved in the aging process with traditional techniques

In a new study, researchers from the Institute of Zoology, Chinese Academy of Sciences and Xuanwu Hospital of Capital Medical University used the brain tissue of non-human primates (NHP) as an ideal model for simulating the aging of the human hippocampus and constructed for the first time The mononuclear transcriptome map of primate hippocampus aging reveals the molecular mechanism of its function degradation with age, and provides a valuable resource for identifying new diagnostic biomarkers and potential therapeutic targets for intervention in the hippocampus Aging and related human neurodegenerative diseases

In this study, these authors found that the aging NHP hippocampus exhibits a series of aging-related damages, including genomic and epigenome instability, loss of protein homeostasis, and increased inflammation

Construction of monkey hippocampus mononuclear transcriptome map, picture from Protein & Cell, 2021, doi:10.

The in-depth analysis of the dynamic gene expression characteristics of the gradual neurogenesis trajectory reveals that TAPC division damage and neuronal function damage are the basis of the early and late adult hippocampal neurogenesis

This study established for the first time a comprehensive mononuclear transcriptome map of primate hippocampus aging, providing a wide range of resources for explaining age-related molecular characteristics at the single-cell level, including the common causes of senile hippocampal nerves.

Reference materials:

Hui Zhang et al.