Chinese scientists have found that vitamin C can promote plasma cell differentiation

Recently, The Changxing team of West Lake University in China found in a study that vitamin C can promote plasma cell differentiation and body fluid immune response by enhancing TET2/3-mediated DNA dna dna to enhance immune response, and thus enhance the body's immunity.
the study, published in the journal Cell Reports, is entitled Ascorbic acid plasma cell cell solution through enhanced TET2/3-mediated DNA demethylation.
cells are an immune cell produced by human B lymphocytes, the body is attacked by pathogens will stimulate pulp cells to produce a large number of antibodies, is an important part of the body's adaptive immune system.
Researchers in in-body plasma cell differentiation determination found that early B lymphocyte biosis process vitamin C treatment can enhance plasma cell differentiation by enhancing TET2/3 mediated DNA demethylation, increase antibody titration and secrete IgG plasma cells, thereby improving human immunity.
same time, by simulating human vitamin C deficiency in mice in the body by using Gulo-/- mice, the researchers demonstrated that vitamin C deficiency significantly reduced the production of antigen post-immune antibodies and plasma cells.
, the absence of Tat2 and Tat3 in mature B lymphocytes completely eliminates the effect of vitamin C on plasma cell differentiation, suggesting that vitamin C promotes plasma cell differentiation through TAT enzymes.
, the study sheds light on a previously unsealed link between vitamin C and the regulation of plasma cell differentiation.
paper link: