Chinese scientists 'portrait' cells of 15 types of tumors

, Beijing, February 7 (Reporter Lin Miaomiao, Chike) cancer species are different, tumor cell composition is also different, resulting in the occurrence and development of tumors have different characteristics. Recently, Chinese scientists systematically characterized tumor-immersed myelin cell characteristics of 15 types of cancers, including stomach cancer, colorectal cancer, liver cancer, lung cancer and breast cancer, from a single-cell level.
the research paper, which was published in the international academic journal Cell, was carried out in collaboration with the team ji Jiafu of Peking University Oncology Hospital and zhang
of the Center for Biomedical Frontier Innovation of Peking University.
team compared the characteristics of myelin cell groups such as fat cells, degeneration cells and tumor-related macrophages in different cancer species, providing an important basis for immunotherapy targeting myelin cells in different cancer species.
, tumors have complex ecosystems, and cancer cells form complex cell control networks by interacting with many other types of cells. Among them, myelin cells play an important role in regulating tumor inflammatory response and angiogenesics, thus becoming another hot target cell in clinical research on cancer treatment after lymphocytes.
is a country with a high incidence of stomach cancer. In their study, the scientists found that the proportion of fat cells in the tumor tissue of stomach cancer was higher than that of normal tissue next to cancer, indicating that the accumulation of fat cells in tumor tissue played an important role in the occurrence and progression of stomach cancer. There are macrophage groups in gastric cancer tumor tissue that increase the signaling pathogenesus associated with angiogenesty, which indicates that macrophage groups play an important role in the micro-environment of stomach cancer tumors.By further integrating the single-cell transcription group sequencing data produced by the team and published public data, the
team constructed a map of myelin cells for 15 cancer species, including stomach cancer, and systematically compared the differences in the composition, development and function of myelin cell groups between different cancer species.
study found that hypertrophic cells show different functional states in multiple cancers, and there are macrophage groups in different types of cancer that increase the signaling path pathogenesus associated with angiogenesty. Macrophages are highly heterogeneous in different cancer species, meaning that in the immunotherapy programme for macrophages, it is particularly important to consider their transcriptional specificity within different cancer species.