Cholesterol into new coronavirus invades cells 'accomplices'

To cause new coronary pneumonia, the new coronavirus must force its way into human cells, and it needs an "accomplice".
cholesterol is a waxy compound known for clogging arterial blood vessels that helps viruses open cells and slide into them, according to Clifford Branwin's lab, a researcher at the Howard Hughes Institute of Medicine in the United States.
papers were published on BioRxiv.org, a recent life sciences preprinted website.
, the virus cannot cause infection by crossing the cell's protective barrier without cholesterol.
" cholesterol is a component of the cell membrane that surrounds cells and some viruses, including the new coronavirus, so it is critical for infection.
" Branwyn said, which could be a better basis for the health of patients with new coronary pneumonia who take statins to lower their cholesterol.
previous studies have shown that these drugs prevent new coronavirus from entering cells by suppressing cholesterol.
, the findings could help researchers develop new ways to treat new coronary pneumonia before most people are vaccinated, said Dr. Bravin.
to simulate a new coronavirus infection, the team designed cells that carry the virus's "sting protein" or human ACE2 protein.
to cause an infection, the virus must fuse its own membrane into the cell membrane.
This process begins when the hedgehog protein arrives at the cell target ACE2: cells with ACE2 grow tiny tentacles attached to the prickly proteins of nearby cells;
experiments, researchers tried to disrupt cell fusion.
that if the cell membrane of the new coronavirus lacks cholesterol, the virus cannot enter the target cells.
report also points out that cholesterol play a very different role in virus invasion among different viruses.
is not clear how cholesterol helps the new coronavirus enter cells.
addition, the study may reveal a strange feature of neo-crown pneumonia: the formation of huge composite cells in the lungs of patients with neo-corona pneumonia -- a similar cytocytocyte that researchers have seen in experiments.
the researchers note that the cells continue to devour each other, and that their inclusions are scattered like eggs broken in a bowl.
cells, known as congenosomes, appear under a microscope, similar to those found in healthy tissues such as muscles and the placenta, and similar to cells in some viral diseases.
: "These experiments are likely to show how giant cells found in a patient's lungs form.
in coronary pneumonia, the formation of the complex can be very harmful, it can damage lung tissue and lead to death.
" (Intern Reporter Zhang Jiaxin)