Cholesterol may cause breast cancer cell therapy to fail

Hypercholesterolemia is an independent risk factor for breast cancer in postmenopausal women

Cholesterol is a basic component of cell membranes

On August 24, 2021, researchers from Duke University School of Medicine published a research paper in the journal Nature Communications titled: Imbalance of cholesterol homeostasis leads to resistance to iron death and increases the tumorigenicity of cancer And transfer

The study showed that long-term exposure to the cholesterol metabolite 27-hydroxycholesterol (27HC) can survive cells that exhibit increased cellular uptake and/or lipid biosynthesis

The research team first evaluated the effect of 27HC on the activity of ER-positive breast cancer cells (MCF7) in exogenous steroid removal medium (CFS) and complete medium (FBS)

Hypercholesterolemia is a chronic disease

Next, the research team evaluated the potential biochemical mechanisms of 27HC resistance and how they promote the malignant transformation of cancer cells

The accumulation of lipids in 27HC resistant cells will also bring considerable metabolic pressure to the cells

In summary, this work emphasizes the universal importance of iron death in tumor growth and metastasis, and shows that dyslipidemia/hypercholesterolemia affects the pathogenesis of cancer by selecting cells that resist iron death

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(Source: Internet, for reference only)