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    Home > Biochemistry News > Biotechnology News > Chondrosulitin lysase enzyme: The long-term destructive problem of spinal cord injury to respiratory function is expected to be solved.

    Chondrosulitin lysase enzyme: The long-term destructive problem of spinal cord injury to respiratory function is expected to be solved.

    • Last Update: 2020-08-06
    • Source: Internet
    • Author: User
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    Millions of people worldwide suffer from chronic spinal cord injury, and injuries to different spinal cord sections can lead to varying degrees of respiratory muscle function.
    generally believe that the long-term damage of spinal cord injury to respiratory function is irreversible.
    but the researchers seem to have found a way to change, at least they found a solution in rats.
    injectad with a special enzyme that helps wake up certain types of nerve cells.
    helping rats regain breathcontrol is only the first step, and if the program continues to move forward, it can help restore part of the rat's motor function, and even eventually to humans, and that is the light that life science brings to patients' dark lives.
    respiratory disorders are the leading cause of death and disability after spinal cord injury, and in the latest trial, rats with long-term (up to a year and a half) spinal cord injuries have regained respiratory control after receiving treatment for enzyme injections, according to a recent paper published in the British journal Nature.
    worldwide, the incidence of spinal cord injury is increasing year by year.
    spinal cord injury is due to a variety of external forces on the spinal cord caused by the compression or fracture of the spinal cord, its treatment and rehabilitation has become a major topic in the medical profession today: and respiratory complications, is the high level of spinal cord injury patients the main cause of early death: the higher the injury site, the greater the impact on respiratory function.
    this is due to the frequent breaks of the nerve fibers that control the respiratory muscles after a spinal cord injury, and the scar tissue that gradually forms around these interrupted nerve fibers, blocking the regenerative attempts to reconnect.
    , it has long been thought that the fibers will die quickly if they are not reconnected quickly after an injury.
    , new experiments by Philip Warren, a researcher at Case Western Reserve University in the United States, and colleagues showed that after injecting the sulphate cosylythse abc into a section of the rat's spine, neurons involved in breathing effectively break down the scar tissue formed after a spinal cord injury.
    researchers found that after the removal of scar tissue, nervegers were significant, and rats with nearly life-long (up to a year and a half) respiratory paralysis eventually regained almost complete respiratory control.
    , the team found that combining intermittent hypoxia enhances recovery and can last up to six months after treatment.
    researchers point out that further research is being carried out on the findings to determine the exact recovery mechanism.
    Source: Science Daily.
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