CID: The relationship between lymphopenia and infection outcome or death in heart transplant recipients one month after transplantation

Background: In heart transplantation, cell-mediated immunity is the specific target of several drugs to prevent or treat rejection
.

Low absolute lymphocyte count (ALC) may become a useful clinical indicator that can indicate the overall risk of infection

In heart transplantation, cell-mediated immunity is the specific target of several drugs to prevent or treat rejection

Results: Of the 375 subjects analyzed, 101 (27%) had a comprehensive outcome (61 CMV, 3 HSV/VZV, 19 BSI, 10 IFI, 8 deaths)
.

Compared with patients without lymphopenia, lymphopenia (ALC<0.
75 x 103 cells/µL) at 1 month is associated with a ratio of more than twice the composite prognosis (hazard ratio 2.

Figure 1 Kaplan-Meier curve shows the survival rate of the composite outcome, stratified according to the presence or absence of lymphopenia; ^a Day 0 is the first day of follow-up, 28 days after transplantation
.

Figure 1 Kaplan-Meier curve shows the survival rate of the composite outcome, stratified according to the presence or absence of lymphopenia; ^a Day 0 is the first day of follow-up, 28 days after transplantation
.

^a

2 and has not experienced a composite profile of result of the ALC; ^A figure displayed (n = 101) in patients with and without (n = 274) integrated ALC distribution of outcomes
.

Each point represents a patient and is overlaid on a standard box plot

2 and has not experienced a composite profile of result of the ALC; ^A figure displayed (n = 101) in patients with and without (n = 274) integrated ALC distribution of outcomes

ALC measured 1 month after heart transplantation is associated with an increased risk of infection or death at 11 months after surgery

Perry WA, Paulus JK, Price LL,et al, Association between lymphopenia at one month post-transplant and infectious outcomes or death in heart transplant recipients .

Association between lymphopenia at one month post- transplant and infectious outcomes or death in heart transplant recipients in this message