CID: Vitamin D3 supplementation can increase the bone mineral density of the spine in adolescents and young adults who use tenofovir fumarate to treat human immunodeficiency virus infections

Purpose: Tenofovir fumarate (TDF) can reduce bone mineral density (BMD)
.

We hypothesized that vitamin D3 (VITD3) would increase the bone density of young people receiving TDF treatment

Tenofovir fumarate (TDF) can reduce bone mineral density (BMD)

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Results: The age of the participants was 22.
0 (21.
0, 23.
0) years old, 84% of them were male and 74% were black/African American
.

At baseline, 62% of people had 25-hydroxyvitamin D (25-OHD) <20 ng/mL

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Figure 1 Serum vitamin D (25-OHD) concentration and lumbar spine (L1-L4) bone mineral density (BMD) changes were performed according to the study week and the vitamin D random dose group
.

The median and histogram of the data are Q1 and Q3

Figure 1 Serum vitamin D (25-OHD) concentration and lumbar spine (L1-L4) bone mineral density (BMD) changes were performed according to the study week and the vitamin D random dose group

FIG 2 vitamin D (25-OHD-based serum) and grouped by ZHOU random vitamin D dose
.

Vitamin D status classification based on the Institute of Medicine classification

FIG 2 vitamin D (25-OHD-based serum) and grouped by ZHOU random vitamin D dose

Table: Multivariate model of lumbar spine (L1-L4) bone mineral density changes from baseline to 48 weeks

Table: Multivariate model of lumbar spine (L1-L4) bone mineral density changes from baseline to 48 weeks

Conclusion: For young people taking TDF-CART , LS BMD increased after taking vitamin D ₃ plus multivitamin for 48 weeks, but taking placebo plus multivitamin did not increase, regardless of baseline vitamin D status
.

For young people taking TDF-CART , LS BMD increased after 48 weeks of taking vitamin D ₃ plus multivitamins, but it did not increase after taking placebo plus multivitamins, regardless of the baseline vitamin D status

Havens PL, Stephensen CB, Van Loan MD,et al, Vitamin D3 Supplementation Increases Spine Bone Mineral Density in Adolescents and Young Adults With Human Immunodeficiency Virus Infection Being Treated With Tenofovir Disoproxil Fumarate: A Randomized, Placebo-Controlled Trial.

Vitamin D3 Supplementation Increases Spine Bone Mineral Density in Adolescents and Young Adults With Human Immunodeficiency Virus Infection Being Treated With Tenofovir Disoproxil Fumarate: A Randomized, Placebo-Controlled Trial.
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