Circ Res: Lai's group reveals the molecular mechanisms of iron deficiency anemia and oral contraceptives that induce stroke.

Ischemic stroke is usually caused by blocked blood vessels, which account for about 87% of strokes.
in short, ischemic stroke occurs after a severe reduction or interruption of cerebral blood flow caused by blocked blood vessels.
, ischemic stroke is the second leading cause of death worldwide and the most important cause of permanent disability.
two seductive factors, including iron deficiency anemia and the use of combined oral contraceptives, were associated with an increased risk of stroke, but their underlying molecular mechanisms were uncertain.
iron deficiency anemia is the world's most common nutritional disorder, affecting more than 2 billion people worldwide.
as early as 30 years ago, iron deficiency anemia was found to be associated with paraplegia and aphdlosis.
In the past few years, the link between iron deficiency anemia and thromboembolism, such as central vein obstruction in the retina, cystic thrombosis in the cerebral veins and cervical arterial thrombosis, has become increasingly recognized.
, numerous studies have shown a significant increase in the risk of stroke in women who use oral contraceptives, which is one of the risk factors for stroke in women of childbearing age.
recently, a team led by Lai Wei, a researcher at the Kunming Institute of Zoology of the Chinese Academy of Sciences, published an article in the journal Siron-Deficiency and Estrogen Are Associated with Ischemic Stroke by Transferin-Regulating to Induce Hypercoagulability, which found that iron deficiency and estrogen were transferred through regulation, respectively. The low oxygen induction element (HRE) and estrogen reaction element (ERE) in the ferrine gene regulatory region increase the expression of translatin, indicating a link between the increase in transirin and iron deficiency anemia and the use of oral contraceptives (this article was selected as the cover article for Issue 5).
previous studies have shown that plasma-to-iron protein interacts with coagulation factors and anticoagulant factors with different affinity forces to maintain the steady state balance of the clotting system.
Further mouse model experiments found that exogenetic translacrotein treatment, iron deficiency anemia, estrogen dosing or trans ferrine over-expression can induce the onset of high coagulation tendency and ischemic stroke, while transirin antibody intervention, transirin knock-down and design of interventional polypeptides can significantly reduce the incidence of stroke.
these data show that increased translatin is a risk factor for stroke and an important associated factor associated with iron deficiency anemia and oral contraceptive-induced thrombosis.
the study further confirmed the central role of transirin in maintaining a steady-state balance of the clotting system.
this study provides a new approach and idea for drug development of thrombosis related to iron deficiency anemia and oral contraceptives.
The first author of the paper is Tang Xiaoxuan Associate Research Fellow, Dr. Fang Mingqian of Kunming Zoology Research Institute, Dr. Cheng Rumei, Associate Researcher zhang Zhiye and Assistant Researcher Shen Chuanbin, and Director Wang Yuming of the Inspection Department of the Second Affiliated Hospital of Kunming Medical University are the co-authors of the paper; and Lai Wei Researcher is the sole correspondent of the paper.
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