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Circular RNA circCCNB1 inhibits migration and invasion of nasopharyngeal carcinoma

 Last Update: 2022-08-10
 Source: Internet
 Author: User

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There are two forms of circular RNA (circCCNB1 and circCcnb1) derived from CCNB1 pre-mR.

Nasopharyngeal carcinoma (NPC) is the most common head and neck malignancy in Southeast Asia and southern China, originating from the epithelial tissue of nasopharyngeal carcino.

Circular RNAs (circRNAs) have closed loop structures and are widely expressed in mammalian cel.

Research by Pr.

Schematic diagram of the binding of circCCNB1 to the 3'UTR of TJP1 mR.

The downstream proteins regulated by circCCNB1 were screened by mass spectromet.

circRIP assay verified the binding of circCCNB1 to TJP1 3'U.

Schematic illustration of circCCNB1 inhibiting nasopharyngeal carcinoma migration and invasion by binding to NF90 and TJP1 mR.

Taken together, this study demonstrates that circCCNB1 is expressed at low levels in NPCs and is associated with NPC migration and invasi.

The research was published in the journal Science China Life Science.

Provided by Scientific China Press

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