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    Home > Active Ingredient News > Study of Nervous System > Circulation | Big Discovery: "Good Cholesterol" can both anti-inflammatory and protect the cardiovascular system

    Circulation | Big Discovery: "Good Cholesterol" can both anti-inflammatory and protect the cardiovascular system

    • Last Update: 2021-05-08
    • Source: Internet
    • Author: User
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    High-density lipoprotein cholesterol ( HDL-C ) is mainly synthesized in the liver and is an anti-atherosclerotic lipoprotein.
    Numerous previous studies have shown that there is an inverse relationship between a decrease in high-density lipoprotein cholesterol and an increased risk of coronary heart disease and myocardial infarction.
    Therefore, the level generally considered the risk that the plasma levels of medsci.
    cn/course/search.
    do?w=%E5%BF%83%E8%A1%80%E7%AE%A1">heart vascular disease (
    CVD risk) was negatively correlated.

    HDL-C),。,medsci.
    cn/course/search.
    do?w=%E5%BF%83%E8%A1%80%E7%AE%A1">(
    medsci.
    cn/course/search.
    do?w=%E5%BF%83%E8%A1%80%E7%AE%A1">CVD)。

    HDL-C(LDL-C),。。HDL-CCVD,,。

    It is almost recognized that HDL-C is good cholesterol.
    This is in contrast to the so-called
    " bad " cholesterol, low-density lipoprotein cholesterol (LDL-C) , which causes cholesterol to accumulate in the arteries and increases the risk of cardiovascular disease.
    .
    However, this view has been challenged in recent years.
    There have been several large-scale clinical research tests.
    There have been several large-scale clinical research tests.
    There have been several large-scale clinical research tests that HDL-C can reduce the risk of CVD, but they have failed to prove that it has a preventive effect on coronary heart disease .
    HDL-C can reduce the risk of CVD, but none of them has proven to have a preventive effect on coronary heart disease .
    prevention

    Although in the general population, the circulating level of HDL-C is inversely proportional to the risk of CVD, the results of drug intervention trials aimed at increasing plasma HDL-C are often negative.
    So does the anti-inflammatory ability of
    HDL-C have a prospective relationship with the first CVD of the general population ? For this reason, experts cardiovascular disease Karolinska Medical School carried out the relevant case-control study, published in the latest "cycle" .
    Circulation
    magazine.

    Although in the general population, the circulating level of HDL-C is inversely proportional to the risk of CVD, it aims to increase plasma HDL-C.
    Although in the general population, the circulating level of HDL-C is inversely proportional to the risk of CVD, it aims to increase plasma HDL.
    -C
    's drug intervention test results are often negative.
    Then the
    result of drug intervention trials often were negative.
    The results of drug intervention trials are often negative.
    Does the anti-inflammatory ability of HDL-C have a prospective relationship with the first CVD of the general population ? For this reason, experts cardiovascular disease Karolinska Medical School carried out the relevant case-control study, published in the latest "cycle" .
    Circulation
    magazine.

    The anti-inflammatory ability of HDL was determined to be its ability to inhibit TNFα- induced VCAM-1 mRNA expression in vitro .
    In the nested case-control design of the
    PREVEND study, the investigator set 8267 eligible subjects as the study cohort.
    Participants
    were grouped according to their age, gender, smoking status, and HDL-C status.

    The anti-inflammatory ability of HDL was determined to be its ability to inhibit TNFα- induced VCAM-1 mRNA expression in vitro .
    In the nested case-control design of the
    PREVEND study, the investigator set 8267 eligible subjects as the study cohort.
    Participants
    were grouped according to their age, gender, smoking status, and HDL-C status.

    At a median 10.
    5
    during the year of follow-up, participants were 369 secondary CVD events (death, ischemic heart disease, non-fatal cardiovascular causes myocardial infarction and coronary revascularization combined endpoint).

    At a median 10.
    5
    during the year of follow-up, participants were 369 secondary CVD events (death, ischemic heart disease, non-fatal cardiovascular causes myocardial infarction and coronary revascularization combined endpoint).
    Myocardial infarction

    Schematic diagram of HDL anti-inflammatory mechanism

    Schematic diagram of HDL anti-inflammatory mechanism

    In general, the anti-inflammatory ability of HDL has nothing to do with HDL-C and hsCRP .
    Compared with the control group, the
    HDL anti-inflammatory ability of CVD patients was significantly lower (31.
    6% vs 27.
    0%; P<0.
    001).
    After multi-factor adjustment, the anti-inflammatory ability of HDL was negatively correlated with the occurrence of CVD (for every 1SD increase in HDL, the risk of CVD was reduced by 26%).

    In general, the anti-inflammatory ability of HDL has nothing to do with HDL-C and hsCRP .
    Compared with the control group, compared
    with the control group, compared with the control group, the HDL anti-inflammatory ability of CVD patients was significantly lower (31.
    6% vs 27.
    0%; P<0.
    001).
    After multi-factor adjustment, the anti-inflammatory ability of HDL was negatively correlated with the occurrence of CVD (for every 1SD increase in HDL, the risk of CVD was reduced by 26%).
    The anti-inflammatory ability of HDL in CVD patients was significantly lower (31.
    6% vs 27.
    0%; P<0.
    001).
    After multi-factor adjustment, the anti-inflammatory ability of HDL was negatively correlated with the occurrence of CVD (for every 1SD increase in HDL, the risk of CVD was reduced by 26%).

    In addition, this association is roughly similar to all the individual components of the CVD endpoint.
    The anti-inflammatory effect of HDL is not related to the ability of cholesterol efflux ( r=-0.
    02
    ; P>0.
    05
    ).
    When these two
    HDL functional indicators are combined into one model, in the fully adjusted model, both are clearly and independently associated with the occurrence of CVD (for every 1SD increase in outflow capacity, the risk of CVD is reduced by 26%; anti-inflammatory capacity For every 1SD increase, CVD risk is reduced by 34%).

    In addition, this association is roughly similar to all the individual components of the CVD endpoint.
    The anti-inflammatory effect of HDL is not related to the ability of cholesterol efflux ( r=-0.
    02
    ; P>0.
    05
    ).
    When these two
    HDL when incorporated into a model function parameters, the model is completely adjusted in both the both and both are with both occur independent CVD obvious association (outflow capability for each additional 1SD, CVD The risk is reduced by 26%; for every 1SD increase in anti-inflammatory ability, the risk of CVD is reduced by 34%).
    The occurrence of CVD has obvious independent correlation (for every 1SD increase in outflow capacity, CVD risk is reduced by 26%; for every 1SD increase in anti-inflammatory capacity, CVD risk is reduced by 34%).

    According to the different anti-inflammatory ability of HDL, the probability of occurrence of CVD event.

    According to the different anti-inflammatory ability of HDL, the probability of occurrence of CVD event.

    It was further found that increasing HDL has a more effective anti-inflammatory ability for women.
    At the same time,
    the anti-inflammatory ability of HDL improves the risk prediction of the Framingham risk score, thereby helping to predict the risk of cardiovascular disease due to arterial stenosis.

    It was further found that increasing HDL has a more effective anti-inflammatory ability for women.
    At the same time,
    the anti-inflammatory ability of HDL improves the risk prediction of the Framingham risk score, thereby helping to predict the risk of cardiovascular disease due to arterial stenosis.
    The anti-inflammatory ability of HDL improves the risk prediction of the Framingham risk score, thereby helping to predict the risk of cardiovascular disease due to arterial stenosis.

    Researchers pointed out that atherosclerosis is increasingly recognized as an inflammation-related disease, and the main biological function of HDL is to reduce inflammation.
    In this cohort, the
    anti-inflammatory ability of HDL , which reflects the protection of blood vessels to the key steps of atherosclerosis , is inversely proportional to the occurrence of CVD, and has nothing to do with the outflow ability of HDL-C and HDL-C.

    Researchers pointed out that atherosclerosis is increasingly recognized as an inflammation-related disease, and the main biological function of HDL is to reduce inflammation.
    In the queue,
    reflecting vascular protection key step in the hardening of atheromatous
    reflect atherosclerotic vascular protection of critical steps reflect atherosclerotic vascular protection key steps of HDL anti-inflammatory ability correlated with the occurrence of CVD Inversely, it has nothing to do with the outflow capacity of HDL-C and HDL-C.
    The anti-inflammatory ability of HDL is inversely proportional to the occurrence of CVD, and has nothing to do with the outflow ability of HDL-C and HDL-C.

    In summary, as a good cholesterol, HDL can not only anti-inflammatory, but also protect the cardiovascular system.
    If the HDL anti-inflammatory ability can be added to the Framingham risk score, it may improve the prediction of cardiovascular risk assessment.

    In summary, as a good cholesterol, HDL can not only anti-inflammatory, but also protect the cardiovascular system.
    If the HDL anti-inflammatory ability can be added to the Framingham risk score, it may improve the prediction of cardiovascular risk assessment.
    In summary, as a good cholesterol, HDL can not only anti-inflammatory, but also protect the cardiovascular system.
    If the HDL anti-inflammatory ability can be added to the Framingham risk score, it may improve the prediction of cardiovascular risk assessment.

     

      

    references:

    references:

    High-Density Lipoprotein Anti-Inflammatory Capacity and Incident Cardiovascular Events.
    https://doi.
    org/10.
    1161/CIRCULATIONAHA.
    120.
    050808Circulation.
    ;0

    High-Density Lipoprotein Anti-Inflammatory Capacity and Incident Cardiovascular Events.
    https://doi.
    org/10.
    1161/CIRCULATIONAHA.
    120.
    050808Circulation.
    ;0
    High-Density Lipoprotein Anti-Inflammatory Capacity and Incident Cardiovascular Events.


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