Circulation | Big Discovery: "Good Cholesterol" can both anti-inflammatory and protect the cardiovascular system

High-density lipoprotein cholesterol ( HDL-C ) is mainly synthesized in the liver and is an anti-atherosclerotic lipoprotein.

（HDL-C），。。，medsci.

It is almost recognized that HDL-C is good cholesterol.

Although in the general population, the circulating level of HDL-C is inversely proportional to the risk of CVD, the results of drug intervention trials aimed at increasing plasma HDL-C are often negative.

Although in the general population, the circulating level of HDL-C is inversely proportional to the risk of CVD, it aims to increase plasma HDL-C.

The anti-inflammatory ability of HDL was determined to be its ability to inhibit TNFα- induced VCAM-1 mRNA expression in vitro .

The anti-inflammatory ability of HDL was determined to be its ability to inhibit TNFα- induced VCAM-1 mRNA expression in vitro .

At a median 10.

Schematic diagram of HDL anti-inflammatory mechanism

Schematic diagram of HDL anti-inflammatory mechanism

In general, the anti-inflammatory ability of HDL has nothing to do with HDL-C and hsCRP .

In general, the anti-inflammatory ability of HDL has nothing to do with HDL-C and hsCRP .

In addition, this association is roughly similar to all the individual components of the CVD endpoint.

According to the different anti-inflammatory ability of HDL, the probability of occurrence of CVD event.

According to the different anti-inflammatory ability of HDL, the probability of occurrence of CVD event.

It was further found that increasing HDL has a more effective anti-inflammatory ability for women.

Researchers pointed out that atherosclerosis is increasingly recognized as an inflammation-related disease, and the main biological function of HDL is to reduce inflammation.

In summary, as a good cholesterol, HDL can not only anti-inflammatory, but also protect the cardiovascular system.

  

references:

references:

High-Density Lipoprotein Anti-Inflammatory Capacity and Incident Cardiovascular Events.
https://doi.
org/10.
1161/CIRCULATIONAHA.
120.
050808Circulation.
;0

High-Density Lipoprotein Anti-Inflammatory Capacity and Incident Cardiovascular Events.
https://doi.
org/10.
1161/CIRCULATIONAHA.
120.
050808Circulation.
;0 High-Density Lipoprotein Anti-Inflammatory Capacity and Incident Cardiovascular Events.
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