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Professor Judith Haendeler of the School of Medicine and Professor Joachim Altschmied, a molecular biologist in the Department of Biology, and their team demonstrated for the first time in the cardiovascular system that the presence of telomerase reverse transcriptase (TERT) in the mitochondria of the power cells of cells has a protective effect on myocardial infarction
.
This work was done in collaboration with other groups at the University Hospital of Düsseldorf and University Hospital of Essen within the framework of the 1116 Cooperative Research Center, and was recently published in the well-known journal "Circulation"
In the cell nucleus, TERT is a component of the so-called "immortal enzyme" telomerase, and the 2009 Nobel Prize in Physiology or Medicine was awarded for the discovery of this enzyme
.
At the same time, two research teams at HHU have demonstrated that TERT is also present in the mitochondria of cells of the cardiovascular system
To this end, Professor Haendeler and Professor Altschmied created a unique mouse model in the world, in which the protein only exists in the nucleus or mitochondria
.
Through these studies, they were able to prove that mitochondria (rather than nuclear TERT) improve cardiac mitochondrial function and reduce the damaged area after a heart attack
Based on these findings, therapies that increase the content of TERT in the mitochondria seem to contribute to a better course of treatment after a heart attack
.
This effect occurs in the heart tissue of patients undergoing pressure cuff therapy in bypass patients
Niloofar Ale-Agha, Philipp Jakobs, Christine Goy, Mark Zurek, Julia Rosen, Nadine Dyballa-Rukes, Sabine Metzger, Jan Greulich, Florian von Ameln, Olaf Eckermann, Klaus Unfried, Fedor Brack, Maria Grandoch, Matthias Thielmann, Markus Kamler, Nilgu?n Gedik, Petra Kleinbongard, Andre Heinen, Gerd Heusch, Axel Gödecke, Joachim Altschmied, Judith Haendeler; Mitochondrial Telomerase Reverse Transcriptase Protects from Myocardial Ischemia/reperfusion Injury by Improving Complex Ischemia/reperfusion Injury by Improving Ahead of Print and Function (2021) online Complex RCULATION (2021)
https://doi.
org/10.