Clin and Trans Gastroenterology: Low albumin 22 binding protein concentration levels were associated with high mortality from alcoholic hepatitis.

Alcoholic hepatitis (AH) has a high mortality rate, and currently the mainstream treatment is hormone therapy, but increases the risk of infection.
studies have shown that large numbers of T-cells that produce IL-22 are associated with disease improvement, which may be associated with increased resistance to infection and liver repair.
activity of IL-22 is regulated by its binding protein (BP) IL-22BP, which is 1000 times more likely to bind to the surface binding receptor.
, it is not known whether IL-22BP can be used as a resistance agent to strictly regulate the function of IL-22 to control AH inflammation.
study aims to explore this.
a prospective cohort study, the researchers collected a continuous number of AH patients between March 2013 and December 2017.
included in the following criteria: Alcohol consumption: For men and women, alcohol withdrawal time is less than 4 weeks.
then take blood and liver tissue samples from all patients.
then quantitatively analyze the differences in levels between IL-22 and IL-22BP using chemical staining of immune tissues.
results showed that IL-22BP expression was found in the livers of both AH patients and healthy controls, and previous studies have determined that the white blood cell substrings in the intestines are the main producers of IL-22BP, with healthy people, non-alcoholic fats Compared with patients with liver and non-alcoholic fatty hepatitis, the plasma IL-22BP in AH patients decreased significantly, and the plasma IL-22 content in AH patients was higher than in healthy controls, but this difference was eliminated on the 90th day.
same time, the researchers observed a significant correlation between low plasma IL-22BP levels and poor one-year survival rates.
, the researchers concluded: This study of IL-22 confirms the key role of IL-22BP in human AH, a protein closely linked to disease processes.
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