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Clin Cancer Res: Alpha-fetoprotein as a prognostic biomarker for hepatocellular carcinoma treated with Atezolizuma+bevacizumab

 Last Update: 2022-05-26
 Source: Internet
 Author: User

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Alpha-fetoprotein (AFP) is the most widely detected serum tumor marker for hepatocellular carcinoma (HCC), and AFP overexpression is thought to be a reflection of more aggressive tumor biology and burden

Atezolizuma+bevacizumab is the new standard of care for systemic-naïve, unresectable hepatocellular carcinoma (HCC)

The researchers used the data from the Phase Ib GO30140 study arm A to determine the optimal time to detect AFP and the cut-off value to distinguish different treatment responses in patients

A ≥75% decrease in AFP at 6 weeks of treatment was used as the cutoff to identify responders, and an AFP increase of ≤10% was used as the cutoff to identify patients with disease control Both AFP cutoffs were associated with longer overall survival and progression-free survival Both AFP cutoffs were associated with longer overall and progression-free survival

AFP response at week 6 of initiation of therapy as a surrogate biomarker of prognosis in patients with hepatocellular carcinoma receiving Atezolizuma + bevacizumab Surrogate biomarkers for prognosis in cancer patients

Original source:

Andrew X.

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