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Clin Cancer Res: Anti-tumor activity and related biomarkers of Wee1 inhibitor Adavosertib (AZD1775) in patients with advanced solid tumors

 Last Update: 2021-07-27
 Source: Internet
 Author: User

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Cell cycle checkpoints give cells time to repair DNA damage and chromatin damage before cell division, thereby avoiding replication disasters

Wee1 kinase inhibitor Adavosertib can stop cell cycle arrest and cause cell death

The study adopted a 3+3 dose escalation design, 21 days as a course of treatment, and Adavosertib was taken once a day on Days 1-5 and Days 8-12

Adavosertib plasma concentration changes

A total of 42 patients were recruited

The dose of Adavosertib is 300 mg once daily

Treatment remission

Six patients (14%) achieved a confirmed partial remission: 4 cases of ovarian cancer and 2 cases of endometrial cancer

Adverse reactions

The most common adverse reactions are gastrointestinal and blood; dose-limiting toxicity is grade 4 hematological toxicity and grade 3 fatigue

In summary, the study evaluated the efficacy of Adavosertib RPh2D once a day for advanced solid tumors.

Original source:

Naoko Takebe, et al.

Safety, Antitumor Activity, and Biomarker Analysis in a Phase I Trial of the Once-daily Wee1 Inhibitor Adavosertib (AZD1775) in Patients with Advanced Solid Tumors

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