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Clin Cancer Res: Efficacy and safety of ramucirumab in the treatment of advanced biliary tract cancer

 Last Update: 2022-04-23
 Source: Internet
 Author: User

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Biliary tract cancer (BTC) is a heterogeneous group of malignancies including intrahepatic cholangiocarcinoma (CCA), extrahepatic cholangiocarcinoma, and gallbladder carcinoma
.

There are few effective treatment options for biliary tract cancer

The current standard first-line palliative treatment for biliary tract cancer is a combination of gemcitabine and cisplatin

This is a single-arm Phase II clinical trial recruiting patients with unresectable, previously treated ECOG 0/1 advanced cholangiocarcinoma, and certain liver, kidney and bone marrow function requirements
.

Ramucirumab dose: 8 mg/kg every 2 weeks

Secondary endpoints included overall response rate (ORR), disease control rate (DCR), overall survival (OS) and toxicity

Progression-Free Survival and Overall Survival

The median treatment duration was 10.
1 weeks
.

Median PFS was 3.

In conclusion, the findings of this study suggest that ramucirumab was well tolerated in patients with advanced cholangiocarcinoma with a PFS similar to other chemotherapy regimens historically used for chemotherapy-refractory cholangiocarcinoma
.

Ramucirumab was well tolerated in patients with advanced cholangiocarcinoma, and its PFS was similar to other chemotherapy regimens historically used for chemotherapy-refractory cholangiocarcinoma Ramucirumab was well tolerated in patients with advanced cholangiocarcinoma Good, and its PFS was similar to other chemotherapy regimens historically used for chemotherapy-refractory cholangiocarcinoma
.

Original source:

Sunyoung Lee; Rachna T.

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