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Clin Cancer Res: The first human phase I study evaluated the application of PI3K/mTOR inhibitor GDC-0084 in patients with glioma

 Last Update: 2021-04-17
 Source: Internet
 Author: User

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Glioblastoma is the most common primary brain tumor.

A total of 47 pretreated patients (2-65 mg) from 8 cohorts were included in the study.

At 45 mg/day, the steady-state concentration of GDC-0084 exceeds the pre-clinical target concentration, producing anti-tumor activity in a xenograft model.

In summary, the results of this study indicate that GDC-0084 exhibits typical PI3K/mTOR inhibitor-related toxicity.

Original source:

Patrick Y Wen, et al.

ncbi.
nlm.
nih.
gov/31937616/" target="_blank" rel="noopener">First-in-Human Phase I Study to Evaluate the Brain-Penetrant PI3K / mTOR Inhibitor GDC-0084 in Patients with Progressive or Recurrent High-Grade Glioma in this message

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