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    Home > Active Ingredient News > Antitumor Therapy > Clin Cancer Res: The therapeutic activity of HDAC inhibitor Remetinostat gel for basal cell carcinoma

    Clin Cancer Res: The therapeutic activity of HDAC inhibitor Remetinostat gel for basal cell carcinoma

    • Last Update: 2021-09-18
    • Source: Internet
    • Author: User
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    Basal cell carcinoma (BCC) is a common cancer in the world.


    In the past, researchers used molecular data of human basal cell carcinoma to screen for drug location and determined that histone deacetylase (HDAC) inhibitors are a potential treatment for basal cell carcinoma


    This is an open-label, single-center Phase II trial that recruits patients with basal cell carcinoma


    Change in tumor diameter at the 8th week

    Change in tumor diameter at the 8th week

    33 tumors from 25 patients were included in the analysis


    The overall response rate was 69.


    Pathological changes before and after treatment

    Pathological changes before and after treatment

    Pharmacodynamic analysis showed that the level of acetylated histone H3 in the skin tissues before and after treatment was similar, but the phosphorylation level was increased


    All in all, the HDAC inhibitor Remetinostat is a well-tolerated and effective local treatment drug that can significantly reduce the disease burden of basal cell carcinoma


    The HDAC inhibitor Remetinostat is a well-tolerated and effective local treatment drug that can significantly reduce the disease burden of basal cell carcinoma.


    Original source:

    James M.


    Phase II Open-Label, Single- Arm Trial to Investigate the Efficacy and Safety of Topical Remetinostat Gel in Patients with Basal Cell Carcinoma

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