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    Home > Active Ingredient News > Infection > Clin Chem: Macrogenome analysis shows clinical SARS-CoV-2 infection and bacterial or viral hyperinfection and implantation?

    Clin Chem: Macrogenome analysis shows clinical SARS-CoV-2 infection and bacterial or viral hyperinfection and implantation?

    • Last Update: 2020-08-05
    • Source: Internet
    • Author: User
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    It took more than two months from the initial description of SARS-CoV-2 to its discovery of widespread spread in the United States.
    despite the long intervals, PCR-specific quantitative reverse transcription (qRT) SARS-CoV-2 testing has been slow and has not been widely tested in the United States.
    macro genome sequencing offers hope for non-biased detection of emerging pathogens without prior knowledge of the identity of the pathogen or its genome sequence.
    to evaluate the macrogenome approach in the context of the current SARS-CoV-2 epidemic, laboratory-confirmed positive and negative samples from Seattle, Washington, were evaluated through macrogenome sequencing and compared with the 2019 Reference Genome Database created prior to the sars-CoV-2.
    in laboratory-validated SARS-CoV-2 cases, we clearly identified a new human betacoronavirus within 36 hours, closely related to the known bat Betacoronavirus.
    samples also showed overinfection or progenitor of human paravirus 3 or Moras, highlighting the need to test SARS-CoV-2 directly rather than using a viral respiratory system to rule out infection.
    RT-PCR-negative samples for SARS-CoV-2 were also negative for macrogenomic analysis, and the rhinovirus a and C were positive.
    , unlike the target SARS-CoV-2 qRT-PCR test, macrogenomic analysis of these SARS-CoV-2 negative samples identified the candidate cause of respiratory symptoms in patients.
    these results demonstrate the value of macrogenomic analysis in monitoring and responding to this and future viral pandemics.
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