Clin Chem: What about viruses or bacteria in children infecting type I interferon?

Fever is !---- one of the main causes of emergency visits for children under 3 years of ageit is still difficult to distinguish between the causes of bacterial and viral infections in patients with feverthis study suggests that specific host biomarkers for viral infections, such as type i interferons (IFNs), may help clinicians make decisions and limit the overuse of antibioticsresearchers used Paxgene TEST tubes and serum seroses to collect blood samples from febrile children (n - 101) being treated in the French paediatric emergency department, who ranged in age from 7 days to 36 months and were confirmed to be infected with a virus or bacteriathe researchers evaluated ifN's performance, quantifying the expression of IFN-stimulating genes using Nanostring ® technology, and requantifying plasma IFN-using digital ELISA technologyresults showed that the serum IFN-cysteine content in children confirmed to be 2% (1/46) of children infected with a viral infection (39/55) was below the quantitative threshold (30 fg/mL) (P-lt; 0.001)the IFN-tumor virus concentration and IFN score in the viral infection group were significantly higher than in the bacterial infection group (P .lt; 0.001)serum IFN-alpha concentration was significantly correlated with IFN score (p-pearson s 0.83)had significant differences between serum IFN-alpha serum concentration and IFN score (area under the curve) in children with fever compared to c-reactive protein (0.83)results showed elevated levels of IFN-alpha in the blood of babies with a virus infectionthe differential properties of IFN-alpha molar concentrations and blood transcription characteristics may show diagnostic advantages and may limit the overuse of antibiotics.