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Clin Exp Allergy: Allergic reactions may be involved in severe COVID-19

 Last Update: 2021-10-19
 Source: Internet
 Author: User

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Coronavirus disease ( COVID-19 ) causes deaths mainly due to severe hypoxic respiratory failure
.

Although inflammatory storm is considered to be the main pathogenesis of severe COVID-19, allergies may be another important mechanism in severe cases.

COVID-19

Recently, a research article was published in Clinical and Experimental Allergy, an authoritative journal in the field of allergic diseases.
Researchers evaluated the anti-SARS-CoV-2-spikeS1 protein-specific IgE (SP-IgE) and anti-SARS-CoV in patients with COVID-19.
-2 Serum levels of nucleocapsid protein-specific IgE (NP-IgE)
.

The researchers also analyzed the correlation between specific IgE levels and clinical severity
.

Pulmonary function tests and bronchial provocation tests were performed during the early recovery period of COVID-19

Serum SP-IgE and NP-IgE levels in critically ill patients were significantly increased, and were correlated with the total lung severity score (TLSS) and PaO2/FiO2 ratio
.

Nucleocapsid protein can be detected in airway and intestinal tissues, and it stains positively with activated mast cells, and can bind to IgE

This shows that allergic reactions may be involved in severe COVID-19
.

Allergic reactions may be involved in severe COVID-19
.

Original source:

Cuiyan Tan.

Hypersensitivity may be involved in severe COVID-19 Leave a message here

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