Clin Exp Allergy: Is the development of eczema still related to gender?

Eczema, also known as atopic dermatitis and atopic eczema, is a common chronic inflammatory skin disease that is usually accompanied by a relapse-remission process
.

It is estimated that as many as 20% of children and 10% of adults are affected by eczema

child

There is consensus that most cases of eczema occur in early childhood at the age of 7, 9, and 10 years; however, little is known about the long-term natural history of this disease
.

It is generally believed that most early childhood cases are cured in childhood, and very few cases develop during adolescence and adulthood.

consensus

The investigators of the Isle of Wight Birth Cohort (IOWBC) study conducted 6 follow-up visits over a period of 26 years.
They were 1, 2, 4, 10, 18, and 26 years of age.
Eczema was evaluated at each follow-up
.

Using data from IOWBC, the purpose of this study is to investigate the natural development process of eczema from infancy to early adulthood to determine the different development trajectories describing the disease over time

Methods: The Isle of Wight birth cohort (n=1,456) was prospectively evaluated at birth, 1 year, 2 years, 4 years, 10 years, 18 years, and 26 years
.

In all assessments, eczema was defined as chronic or chronic recurrent pruritic dermatitis lasting more than 6 weeks, with a characteristic shape and distribution in the past 12 months

Results: In men and women, the development trajectory of eczema is as follows: unaffected/temporary (male: 77.
7% vs.
female: 73.
0%), moderate onset and late regression (male: 7.
8% vs.
female: 4.
4%), Late onset (male: 5.
2% vs.
female: 9.
5%), and early onset persistence (male: 9.
3% vs.
female: 5.
4%)
.

Among women, another trajectory was found: early-onset premature withdrawal (7.

In short, we describe the natural process and development trajectory of eczema from infants to early adulthood
.

Our results indicate that men and women may experience different eczema courses and different risk factors

FLG LOF variants and paternal eczema are associated with a higher risk of early onset trajectories in men, while maternal eczema and high birth weight are associated with early onset trajectories in women

Literature source: Ziyab AH, Mukherjee N, Zhang H, Sex-specific developmental trajectories of eczema from infancy to age 26 years: a birth cohort study, Clin Exp Allergy 2021 Dec 01;

Ziyab AH, Mukherjee N, Zhang H,Sex-specific developmental trajectories of eczema from infancy to age 26 years: a birth cohort study, Clin Exp Allergy 2021 Dec 01;

 

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