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With the increasing incidence, pancreatic ductal adenocarcinoma (PDAC) has become the third leading cause of malignant tumor-related deaths
Before the occurrence of PDAC, the patient will have elevated fasting blood glucose
Researchers such as Brewer conducted a case-control study comparing PDAC patients in a tertiary care facility from January 2011 to November 2019 with matched control individuals
HbA1c changes in PDAC patients and controls
HbA1c changes in PDAC patients and controlsA total of 4626 patients met the inclusion criteria: 1542 PDAC cases and 3084 controls; the median age was 69.
In the 3 years before the diagnosis, the HbA1c level of the PDAC patients was higher than that of the control (p≤0.
Changes in BMI of PDAC patients and controls
Changes in BMI of PDAC patients and controlsExcept for the low BMI value in the 0-6 months before cancer diagnosis , the BMI of PDAC cases during the study period was higher than that of the control (p<0.
Diagnosis compared to the control group of patients diagnosed before 1 year and BMI change (△ BMI) at 6 months were higher compared with the control, BMI change (△ when the patient group diagnosed before 1 year and 6 months BMI) are higher than the control group
Multivariate logistic regression analysis showed that HbA1c slope (aOR 1.
HbA1c slope HbA1c slope and BMI slope and BMI slope are both predictive factors of PDAC are predictive factors of PDAC
In summary, patients with PDAC will experience increased blood sugar and weight loss before diagnosis
PDAC patients will experience increased blood sugar and weight loss before diagnosis
Original source:
Brewer Marlon J,Doucette John T,Bar-Mashiah Ariel et al.
Glycemic changes and weight loss precede pancreatic ductal adenocarcinoma by up to three years in a diverse population
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