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Bile acid is an amphiphilic molecule produced by the liver.
Its main function is to increase the dissolution of lipids into micelles to assist digestion and absorption
.
Disruption of the stability of the bile acid home environment may cause too much bile acid to enter the colon, which can cause diarrhea by affecting the electrolyte balance and accelerating the transmission of the large intestine
Bile acid is an amphiphilic molecule produced by the liver.
The researchers conducted the following questionnaire surveys on patients with positive IBS-D diagnosed by Rome III criteria: Inflammatory Activity Questionnaire for Bowel Disease, Hospital Anxiety and Depression (HAD) Scale, General Quality of Life Score QOL (SCL-90) and IBS Specificity Sexual QOL (IBS-Quality of Life)
.
In addition, researchers defined BAD as a patient with fasting serum C4>52.
The results of the study showed that of the 219 IBS-D patients (79% women), 44 had BAD; compared with the group without BAD, the BAD group was significantly older and had a higher body mass index (BMI)
.
Compared with IBS-D without BAD, patients with BAD have more severe bowel dysfunction
This study confirmed that: Compared with IBS-D without BAD, IBS-D with BAD has a greater impact on intestinal and physical symptoms and quality of life
.
The appearance of BAD in IBS-D patients is associated with more severe and frequent diarrhea and a higher need for toilets
Compared with IBS-D without BAD, IBS-D with BAD has a greater impact on intestinal and physical symptoms and quality of life
Joelle BouSaba.
Impact of Bile Acid Diarrhea in Patients with Diarrhea-Predominant Irritable Bowel Syndrome on Symptoms and Quality of Life.
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