Clin Gastroenterology H: Comparison of pregnancy times in women with and without inflammatory bowel disease

Background and objectivesstudies have shown that patients are usually diagnosed with inflammatory bowel disease (IBD)at their peak reproductive yearsThe purpose of this study was to investigate how IBD affects fertilitymethods
researchers collected data from the Danish National Birth Cohortstudy Study, which conducted a national study of 92,274 pregnant women recruited between 1996 and 2002Women who actively tried to conceive reported their pregnancy time by computer-assisted telephone interview at about 16 weeks of pregnancyInformation about IBD is available from the Danish National Patient RegisterUsing regression models and adjusting for important confounding factors, the duration of pregnancy was compared between women with and without IBDresultsthe researchers calculated the duration of pregnancy in 74,471 women without IBD, 340 pregnancies in womenulcerative colitis(UC) and 206 pregnancies in women with Crohn's disease (CD)Compared to non-IBD pregnancies, the relative risk ratio of pregnancy over 12 months for pregnant women with IBD, UC and CD was 1.28 (95% CI, 0.99-1.65), 1.10 (95% CI, 0.80-1.51) and 1.54 (95% CI, 1.03-2.30)Compared to non-IBD pregnancies, the relative risk ratio of correction for women who underwent CD surgery before conception was 2.54 (95% CI, 1.39-4.65) at the time of pregnancy conclusions
in a study of women with IBD, women who had CD, especially those who underwent surgery, had significantly longer delays in pregnancy than women without IBD This indicates a decrease in fertility in the IBD female subgroup