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Non-selective beta-blockers (NSBB) can exert other beneficial effects besides lowering hepatic venous pressure gradient (HVPG), which may be particularly important in patients with decompensated liver cirrhosis (DC), in these patients , Bacterial translocation and induced systemic inflammation can lead to complications, such as acute chronic liver failure (ACLF)
This study confirmed that the reduction of VWF after NSBB treatment reflects their anti-inflammatory activity and is independently associated with the risk of further decompensation, ACLF, and death
Original source:
Mathias Jachs.
Decreasing VWF-levels upon NSBB-therapy indicate a decreased risk of further decompensation, ACLF, and death.
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