echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Digestive System Information > Clin Gastroenterology H: Electromagnetic sphincter enhancer better than proton pump inhibitors on gastroesophageal reflux

    Clin Gastroenterology H: Electromagnetic sphincter enhancer better than proton pump inhibitors on gastroesophageal reflux

    • Last Update: 2020-07-10
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com
    Background and targetgastroesophageal reflux disease (GERD) is caused by mechanical failure of the anti-reflux barrierIn this randomized trial, the researchers compared the effects of sphincter muscle enhancement (MSA) with proton pump inhibitors (PPIs)Methodsresearchers randomly divided patients (n s 152) who had a daily PPI treatment but had moderate to severe reflux (assessed through the preintestinal symptom questionnaire) and were treated with EILYsion (n s 102) or laparoscopic MSA (n s 50) two times a dayThis was conducted between July 2015 and February 2017These patients answered questions about reflux, heartburn, dysphagia, bloating, diarrhea, flatulence and drug use at baseline and 6 months after treatment in the preintestinal-specific reflux questionnaire and GERD-related quality of life surveys related to reflux, heartburn, dysphagia, bloating, diarrhea, bloating and drug useSix months after PPI treatment, MSA is provided to patients with persistent moderate to severe reflux and excess reflux during the drug's impedance or pH test1 year to evaluate reflux, preintestinal fractions, esophageal acid exposure and adverse reactionsresultspatients in the MSA group had similar outcomespatients transferred to the MSA group after treatment with PPI (n s 75)MSA controls reflux (96%) in 72/75 patients; Only 8/43 patients (19%) who received PPI reported reflux controlOf the 75 patients receiving MSA, 61 (81%) had improved GERD health-related quality of life improvement scores (greater than 50%) and 68 (91%) stopped using PPI dailyThe proportion of patients with dysphagia decreased from 15% to 7% (P.005), the proportion of bloating decreased from 55% to 25%, and the exposure time of esophageal acid decreased from 10.7% to 1.3% (P .001)ONE YEAR AFTER MSA (merge P.001) When the study was completed, the pH level was normalized in 70 percent (48/69) of patients conclusions msA reduced reflux by 95% of moderate to severe reflux patients, despite a daily PPI treatment MSA is better than two PPI treatments per day in reducing reflux
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.